STAT5B 蛋白, Human (His)

The STAT5B protein plays dual roles in signal transduction and transcriptional activation in response to KITLG/SCF and growth factors. STAT5B Protein, Human (His) is the recombinant human-derived STAT5B protein, expressed by E. coli , with C-6*His labeled tag. The total length of STAT5B Protein, Human (His) is 321 a.a., with molecular weight of ~38.0 kDa.

STAT5B 是一种多功能蛋白，协调信号转导和转录激活，在细胞对各种刺激（包括细胞因子 KITLG/SCF 和其他生长因子）的反应中发挥关键作用。作为转录因子，STAT5B 与 GAS 元件结合并促进 PRL 诱导的转录，正向调节造血/红细胞分化。激活后，它与相关家族成员形成同二聚体和异二聚体，从而发挥其不同的功能作用。此外，STAT5B 参与蛋白质-蛋白质相互作用，包括与 NR3C1 结合以及与 NCOA1、NMI 和 SOCS7 形成复合物。值得注意的是，在 SH2 结构域的促进下，它与 INSR 的相互作用凸显了它参与胰岛素信号传导。此外，与 CPEB3 的相互作用可以抑制 STAT5B 介导的转录激活，为其多样化的细胞功能增加一层调控复杂性。

Human

E. coli

C-6*His

P51692 (M1-T321)

6777  [NCBI]

MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATIT

Approximately 38.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 10% Trehalose, 1 mM DTT, 0.05% Tween 80, pH 8.5.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.