STC2/Stanniocalcin-2 蛋白, Human (HEK293, His)

STC2/Stanniocalcin-2 Protein plays a vital role in maintaining calcium and phosphate homeostasis and exhibits strong anti-hypocalcemic effects. As a homodimer with disulfide linkages, STC2 plays a crucial structural role in regulating calcium and phosphate balance. This unique property emphasizes the pivotal role of STC2 in preserving the delicate equilibrium of essential minerals in the body. STC2/Stanniocalcin-2 Protein, Human (HEK293, His) is the recombinant human-derived STC2/Stanniocalcin-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of STC2/Stanniocalcin-2 Protein, Human (HEK293, His) is 278 a.a., with molecular weight of 33-43 kDa.

STC2 是钙和磷酸盐稳态的关键参与者，具有有效的抗低钙血症作用。STC2 作为具有二硫键的同型二聚体，在调节与钙和磷酸盐水平平衡相关的调节反应方面表现出结构重要性。这一独特的特性强调了 STC2 在维持生理环境内必需矿物质的复杂平衡方面的关键作用。

Measured by its ability to inhibit Wnt-3a-induced alkaline phosphatase production by MC3T3-E1 mouse preosteoblast cells. The ED₅₀ for this effect is 23.21 ng/mL in the presence of 10 ng/mL of Recombinant Mouse Wnt-3a, corresponding to a specific activity is 4.308×10⁴ U/mg.

• 
  Measured by its ability to inhibit Wnt-3a-induced alkaline phosphatase production by MC3T3‑E1 mouse preosteoblast cells. The ED₅₀ for this effect is 23.21 ng/mL in the presence of 10 ng/mL of Recombinant Mouse Wnt‑3a, corresponding to a specific activity is 4.308×10⁴ U/mg

Human

HEK293

C-His

O76061 (T25-R302)

8614  [NCBI]

TDATNPPEGPQDRSSQQKGRLSLQNTAEIQHCLVNAGDVGCGVFECFENNSCEIRGLHGICMTFLHNAGKFDAQGKSFIKDALKCKAHALRHRFGCISRKCPAIREMVSQLQRECYLKHDLCAAAQENTRVIVEMIHFKDLLLHEPYVDLVNLLLTCGEEVKEAITHSVQVQCEQNWGSLCSILSFCTSAIQKPPTAPPERQPQVDRTKLSRAHHGEAGHHLPEPSSRETGRGAKGERGSKSHPNAHARGRVGGLGAQGPSGSSEWEDEQSEYSDIRR

33-43 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.