2. Gene
  3. STC2 - stanniocalcin 2 Gene

STC2 - stanniocalcin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：斯钙素 2

种属: Homo sapiens

同用名: STC-2; STCRP

基因 ID: 8614 | 基因类型: protein coding

关于 STC2

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:173,314,723-173,328,414 (from NCBI)

This gene has 5 transcripts (splice variants), 260 orthologues and 1 paralogue. Biased expression in placenta (RPKM 12.8), thyroid (RPKM 5.0) and 12 other tissues.

功能概要

该基因编码一种分泌型同型二聚体糖蛋白，该糖蛋白在多种组织中表达，并可能具有自分泌或旁分泌功能。编码的蛋白质在其 15 个半胱氨酸残基中有 10 个在斯钙素家族成员中是保守的，并且仅在其丝氨酸残基上被酪蛋白激酶 2 磷酸化。它的 C 端含有一簇可与金属离子相互作用的组氨酸残基。该蛋白质可能在肾脏和肠道钙和磷酸盐转运、细胞代谢或细胞钙/磷酸盐稳态的调节中发挥作用。人斯钙素 2 在小鼠中的组成型过表达导致出生前和出生后生长受限、骨骼和骨骼肌生长减少以及器官肿大。该基因的表达由雌激素诱导，并在某些乳腺癌中发生改变。[RefSeq 提供，2008 年 7 月]

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by Casein Kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008]

STC2 基因产物(1)

mRNA Protein Name
NM_003714.3 NP_003705.1 stanniocalcin-2 precursor

STC2 蛋白结构

Stanniocalcin

Stanniocalcin: Stanniocalcin family (8 - 218)

  • 0
  • 100
  • 200
  • 302 a.a.
蛋白主名 其他名称

stanniocalcin-2

STC-related protein

重组 STC2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76095 STC2/Stanniocalcin-2 Protein, Human (HEK293, Fc) O76061 (T25-R302) ≥95%
HY-P76096 STC2/Stanniocalcin-2 Protein, Human (HEK293, His) O76061 (T25-R302) ≥95%

关联疾病

疾病名称 别名
Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma

RCC

Nonpapillary Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Hypernephroma

Adenocarcinoma Of Kidney

Renal Carcinoma, Chromophobe, Somatic

Clear Cell Carcinoma Of Kidney

Clear-Cell Metastatic Renal Cell Carcinoma

Clear Cell Renal Carcinoma

Renal Cell Carcinoma, Somatic

Conventional Renal Cell Carcinoma

Conventional Renal Cell Carcinoma

Renal Clear Cell Carcinoma

Ccrcc

Hereditary Clear Cell Renal Cell Carcinoma

Carcinoma, Renal Cell

Renal Cell Carcinoma, Clear Cell, Somatic

Renal Cell Carcinoma, Clear Cell

Clear Cell Kidney Carcinoma

Clear Cell Rcc

Cystic-Multilocular Variant

Clear Cell Renal Cell Adenocarcinoma

Hereditary Clear Cell Renal Cell Adenocarcinoma

Common Renal Cell Carcinoma

Crcc

Renal Cell Carcinoma Non-Papillary

Carcinoma Renal Cell

Renal Cell Cancer

Carcinoma, Renal Cell, Nonpapillary
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13904 STC2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus STC2 RGD RGD:621777
Mus musculus STC2 MGD MGI:1316731
Felis catus STC2 VGNC VGNC:102337
Macaca mulatta STC2 VGNC VGNC:77910
Bos taurus STC2 VGNC VGNC:35378
Canis familiaris STC2 VGNC VGNC:46896
Others STC2 NCBI
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