SULT1C2 蛋白, Human (His)

The SULT1C2 protein utilizes PAPS to catalyze sulfate conjugation and has specific affinity for sulfonated p-nitrophenol. It selectively avoids sulfonated steroids, dopamine, acetaminophen or alpha-naphthol. SULT1C2 Protein, Human (His) is the recombinant human-derived SULT1C2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of SULT1C2 Protein, Human (His) is 296 a.a., with molecular weight of ~38.0 kDa.

SULT1C2 蛋白是一种利用 3'-磷酸-5'-腺苷基硫酸盐 (PAPS) 作为磺酸盐供体的磺基转移酶，在催化硫酸盐缀合中发挥着关键作用，对磺化对硝基苯酚（一种小酚类化合物）具有特定的亲和力。值得注意的是，SULT1C2 在其底物偏好方面表现出选择性，因为它不会磺化类固醇、多巴胺、对乙酰氨基酚或 α-萘酚。此外，这种磺基转移酶还能催化致癌化合物 N-Hydroxy-2-acetaminoflorene 的磺化，从而形成能够产生 DNA 加合物的高反应性中间体。这种酶活性引起了人们对潜在诱变的担忧，强调了 SULT1C2 在外源化合物代谢中的复杂作用及其对与诱变风险相关的细胞过程的影响。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

E. coli

N-6*His

O00338 (M1-L296)

6819  [NCBI]

MALTSDLGKQIKLKEVEGTLLQPATVDNWSQIQSFEAKPDDLLICTYPKAGTTWIQEIVDMIEQNGDVEKCQRAIIQHRHPFIEWARPPQPSGVEKAKAMPSPRILKTHLSTQLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQILFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTVSKSILDQSISSFMRKGTVGDWKNHFTVAQNERFDEIYRRKMEGTSINFCMEL

Approximately 38.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 100 mM NaCl, pH 8.5.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.