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  2. SULT1C2 - sulfotransferase family 1C member 2 Gene

SULT1C2 - sulfotransferase family 1C member 2 Gene

中文名称:磺基转移酶家族 1C 成员 2

种属: Homo sapiens

同用名: ST1C1; ST1C2; SULT1C1; humSULTC2

基因 ID: 6819 | 基因类型: protein coding

关于 SULT1C2

Cytogenetic location: 2q12.3 Genomic coordinates (GRCh38): 2:108,288,895-108,309,915 (from NCBI)

This gene has 9 transcripts (splice variants), 152 orthologues and 12 paralogues. Biased expression in stomach (RPKM 61.8), kidney (RPKM 26.2) and 3 other tissues.

功能概要

磺基转移酶催化许多激素、神经递质、药物和异生化合物的硫酸盐结合。这些胞质酶的组织分布和底物特异性不同。家族成员之间的基因结构 (外显子的数量和长度) 相似。该基因编码属于 SULT1 亚家族的蛋白质,负责将磺基部分从 PAPS 转移到含酚化合物。已针对该基因描述了编码不同同种型的两种可变剪接转录物变体。[RefSeq 提供,2008 年 7 月]

Sulfotransferase Enzymes catalyze the sulfate conjugation of many Hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic Enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that belongs to the SULT1 subfamily, responsible for transferring a sulfo moiety from PAPS to phenol-containing compounds. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

SULT1C2 基因产物(2)

mRNA Protein Name
NM_001056.4 NP_001047.1 sulfotransferase 1C2 isoform a
NM_176825.3 NP_789795.1 sulfotransferase 1C2 isoform b
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables aryl sulfotransferase activity IDA
IDA: 通过直接分析推断
10783263 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21044950 GOA
enables sulfotransferase activity IDA
IDA: 通过直接分析推断
19548878 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within sulfation IDA
IDA: 通过直接分析推断
19548878 GOA
involved in sulfation IDA
IDA: 通过直接分析推断
10783263 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SULT1C2 蛋白结构

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (39 - 288)

  • 0
  • 100
  • 200
  • 296 a.a.
蛋白主名 其他名称

sulfotransferase 1C2

SULT1C#1

重组 SULT1C2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71012 SULT1C2 Protein, Human (His) O00338 (M1-L296) ≥95%

直系同源

种属 基因名 来源 基因 ID
Mus musculus SULT1C2 MGD MGI:1916333
Macaca mulatta SULT1C2 VGNC VGNC:106228
Rattus norvegicus SULT1C2 RGD RGD:1305885
Felis catus SULT1C2 VGNC VGNC:81231
Canis familiaris SULT1C2 VGNC VGNC:46977
Others SULT1C2 NCBI