Syntaxin-7 蛋白, Rat (HEK293, His)

Syntaxin-7 protein is a central player in protein trafficking and membrane fusion events. It guides proteins from the plasma membrane to early endosomes, facilitates homotypic fusion of endocytic organelles, and mediates transport from early endosomes to late endosomes and lysosomes. Syntaxin-7 Protein, Rat (HEK293, His) is the recombinant rat-derived Syntaxin-7 protein, expressed by HEK293 , with N-His labeled tag. The total length of Syntaxin-7 Protein, Rat (HEK293, His) is 237 a.a., with molecular weight of ~30 kDa.

Syntaxin-7 蛋白在与蛋白质运输和膜融合事件相关的细胞过程中发挥着关键作用。它涉及蛋白质从质膜到早期内体 (EE) 的运输，并有助于内吞细胞器的同型融合。此外，Syntaxin-7 在介导从早期内体到晚期内体和溶酶体的内吞运输中发挥着关键作用。与 VPS11、VPS16、VPS18 和 VPS33A 的相互作用强调了其参与内体动力学。此外，Syntaxin-7 与 VTI1B、STX8 和 VAMP8 形成 SNARE 复合物，这对于晚期内涵体的同型融合至关重要。它也是 SNARE 复合体与 STX7、STX8、VAMP7 和 VTI1B 的组成部分，对于晚期内涵体与溶酶体的异型融合至关重要。与 TPC1 的相互作用进一步表明它参与了复杂的细胞过程。研究 Syntaxin-7 相互作用和功能的详细机制可以为其在内吞途径中的膜运输和融合事件中的作用提供有价值的见解。

Immobilized Rat Syntaxin-7 at 2 μg/mL (100 μL/well) can bind Anti- Syntaxin-7 Antibody, The ED₅₀ for this effect is 0.01394 μg/mL.

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  Immobilized Rat Syntaxin-7 at 2 μg/mL (100 μL/well) can bind Anti- Syntaxin-7 Antibody, The ED₅₀ for this effect is 0.01394 μg/mL.

Rat

HEK293

N-6*His

O70257/NP_068641.2 (S2-L238)

60466  [NCBI]

SYTPGIGGDPAQLAQRISSNIQKITQCSAEIQRTLNQLGTPQDTPELRQQLQQEQQYTNQLAKETDKYIKEFGFLPTTPSEQRQRKIQKDRLVAEFTTALTNFQKVQRQAAEREKEFVARVRASSRVSGGFPEDSSKEKNFVSWESQTQPQVQVQDEEITEDDLRLIHERESSIRQLEADIMDINEIFKDLGMMIHEQGDVIDSIEANVESAEVHVQQANQQLSRAANYQRKSRKTL

Approximately 30 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.