1. 重组蛋白
  2. Cytokines and Growth Factors Biotinylated Proteins
  3. Chemokine & Receptors
  4. CC Chemokines
  5. CCL17
  6. TARC/CCL17 蛋白, Dog (Biotinylated, MBP, His-Avi)

TARC/CCL17 蛋白, Dog (Biotinylated, MBP, His-Avi)

目录号: HY-P702846
COA 产品使用指南

TARC/CCL17 蛋白吸引 T 淋巴细胞,特别是 Th2 细胞,并参与炎症和免疫。它与 T 细胞上的 CCR4 结合,导致 GM-CSF/CSF2 诱导的疼痛和炎症。在大脑中,它维持海马小胶质细胞的形态并有助于适应神经炎症。此外,它还通过促进成纤维细胞迁移在伤口愈合中发挥作用。TARC/CCL17 蛋白, Dog (Biotinylated, MBP, His-Avi) 是重组的 TARC/CCL17 蛋白,由 E. coli 表达,带有 N-MBP, C-6*His-Avi 标签。

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描述

The TARC/CCL17 protein attracts T lymphocytes, particularly Th2 cells, and is involved in inflammation and immunity. It binds to CCR4 on T cells and contributes to GM-CSF/CSF2-induced pain and inflammation. In the brain, it maintains hippocampal microglia morphology and aids in adapting to neuroinflammation. Additionally, it plays a role in wound healing by promoting fibroblast migration. TARC/CCL17 Protein, Dog (Biotinylated, MBP, His-Avi) is the recombinant dog-derived TARC/CCL17 protein, expressed by E. coli , with N-MBP, C-6*His-Avi labeled tag.

研究背景

TARC/CCL17 蛋白作为一种趋化因子,对 T 淋巴细胞(特别是 Th2 细胞)具有特异性趋化活性,但对单核细胞或粒细胞没有这种吸引力。它的参与延伸到各种炎症和免疫过程,并通过与 T 细胞表面的 CCR4 结合而促进。此外,TARC/CCL17 还会导致 GM-CSF/CSF2 驱动的疼痛和炎症。在大脑中,这种趋化因子对于在稳态条件下维持海马小胶质细胞特征性的高度分支形态至关重要,并且可能在急性脂多糖(LPS)诱导的神经炎症期间调整小胶质细胞形态和突触可塑性方面发挥关键作用。此外,TARC/CCL17 在伤口愈合中发挥着重要作用,主要是通过诱导成纤维细胞迁移到伤口中。

种属

Dog

表达系统

E. coli

标签

C-6*His;C-Avi;N-MBP

蛋白编号

Q95N01 (A24-S99)

基因 ID

403586

蛋白结构
N-term
MBP
CCL17 (A24-S99)
Accession # Q95N01
6*His-Avi
C-term
同用名
rHuTARC/CCL17; C-C motif chemokine 17; SCYA17
氨基酸序列

ARGTNVGRECCLEYFKGAIPISRLTRWYKTSGECPKDAIVFVTVQGKSICSDPKDKRVKKAVRYLQRTWKGGPQES

分子量

60 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

TARC/CCL17 Protein, Dog (Biotinylated, MBP, His-Avi) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
TARC/CCL17 Protein, Dog (Biotinylated, MBP, His-Avi)
目录号:
HY-P702846
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