TARC/CCL17 蛋白, Dog (HEK293, His)

The TARC/CCL17 protein attracts T lymphocytes, particularly Th2 cells, and is involved in inflammation and immunity. It binds to CCR4 on T cells and contributes to GM-CSF/CSF2-induced pain and inflammation. In the brain, it maintains hippocampal microglia morphology and aids in adapting to neuroinflammation. Additionally, it plays a role in wound healing by promoting fibroblast migration. TARC/CCL17 Protein, Dog (HEK293, His) is the recombinant dog-derived TARC/CCL17 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TARC/CCL17 Protein, Dog (HEK293, His) is 76 a.a., with molecular weight of 10.8 kDa.

TARC/CCL17 蛋白作为一种趋化因子，对 T 淋巴细胞（特别是 Th2 细胞）具有特异性趋化活性，但对单核细胞或粒细胞没有这种吸引力。它的参与延伸到各种炎症和免疫过程，并通过与 T 细胞表面的 CCR4 结合而促进。此外，TARC/CCL17 还会导致 GM-CSF/CSF2 驱动的疼痛和炎症。在大脑中，这种趋化因子对于在稳态条件下维持海马小胶质细胞特征性的高度分支形态至关重要，并且可能在急性脂多糖（LPS）诱导的神经炎症期间调整小胶质细胞形态和突触可塑性方面发挥关键作用。此外，TARC/CCL17 在伤口愈合中发挥着重要作用，主要是通过诱导成纤维细胞迁移到伤口中。

Dog

HEK293

C-6*His

Q95N01 (A24-S99)

403586  [NCBI]

ARGTNVGRECCLEYFKGAIPISRLTRWYKTSGECPKDAIVFVTVQGKSICSDPKDKRVKKAVRYLQRTWKGGPQES

13 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, 6% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.