PNS-Tau/MAPT 蛋白, Mouse (HEK293, His)

Microtubule-associated protein tau (MAPT) plays a key role in promoting microtubule assembly and stability, suggesting its potential contribution to the establishment of neuronal polarity.The C terminus binds to axonal microtubules, whereas the N terminus interacts with neuroplasmic membrane components, serving as a key linker protein between these structures.PNS-Tau/MAPT Protein, Mouse (HEK293, His) is the recombinant mouse-derived PNS-Tau/MAPT protein, expressed by HEK293 , with N-10*His labeled tag.

微管相关蛋白 tau (MAPT) 是促进微管组装和稳定性的关键因素，表明它可能参与神经元极性的建立和维持。其 C 末端与轴突微管结合，而 N 末端与神经质膜成分相互作用，表明 tau 蛋白作为桥接这些细胞结构的关键连接蛋白的作用。预定的轴突极性由 tau 在神经元细胞内的定位决定，特别是在中心体定义的区域中。MAPT 的短亚型有助于细胞骨架的可塑性，而较长的亚型可能优先在其稳定性方面发挥作用。MAPT 与 MARK1、MARK2、MARK3、MARK4、SQSTM1、PSMC2、FKBP4、CSNK1D、SGK1、EPM2A、PIN1、LRRK2 和 LRP1 等多种蛋白质进行多种相互作用，参与从泛素化到去磷酸化和内吞作用的过程。这些复杂的相互作用凸显了 MAPT 在细胞动力学方面的多方面参与。

Mouse

HEK293

N-10*His

P10637-1 (A2-L733)

17762  [NCBI]

ADPRQEFDTMEDHAGDYTLLQDQEGDMDHGLKESPPQPPADDGAEEPGSETSDAKSTPTAEDVTAPLVDERAPDKQAAAQPHTEIPEGITAEEAGIGDTPNQEDQAAGHVTQGRREGQAPDLGTSDWTRQQVSSMSGAPLLPQGLREATCQPSGTRPEDIEKSHPASELLRRGPPQKEGWGQDRLGSEEEVDEDLTVDESSQDSPPSQASLTPGRAAPQAGSGSVCGETASVPGLPTEGSVPLPADFFSKVSAETQASQPEGPGTGPMEEGHEAAPEFTFHVEIKASTPKEQDLEGATVVGVPGEEQKAQTQGPSVGKGTKEASLQEPPGKQPAAGLPGRPVSRVPQLKARVASKDRTGNDEKKAKTSTPSCAKAPSHRPCLSPTRPTLGSSDPLIKPSSPAVSPEPATSPKHVSSVTPRNGSPGTKQMKLKGADGKTGAKIATPRGAASPAQKGTSNATRIPAKTTPSPKTPPGSGEPPKSGERSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSASKSRLQTAPVPMPDLKNVRSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL

78.9 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.