Mapt - microtubule-associated protein tau Gene

中文名称：微管相关蛋白 tau

种属: Mus musculus

同用名: Tau; Mtapt; PHF-tau

关于 Mapt

功能概要

该基因编码的蛋白可启动 DNA 结合活性；微管结合活性；和蛋白激酶结合活性。参与微管蛋白去乙酰化的负调控；调节细胞对热的反应；和调节对 DNA 损伤刺激的反应。在几个过程的上游或内部行动，包括成人步行行为；神经元的产生；并沿微管运输。位于多个细胞成分中，包括细胞骨架；神经胶质细胞投射；和突触后密度。以多种结构表达，包括肠道；神经系统;感觉器官；平滑肌组织；和泌尿系统。用于研究阿尔茨海默病。该基因的人类直系同源物与痴呆症有关（多个）；神经退行性疾病（多种）；进行性核上性麻痹；和颞叶癫痫。与人类 MAPT（微管相关蛋白 tau）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA binding activity; microtubule binding activity; and protein kinase binding activity. Involved in negative regulation of tubulin deacetylation; regulation of cellular response to heat; and regulation of response to DNA damage stimulus. Acts upstream of or within several processes, including adult walking behavior; generation of neurons; and transport along microtubule. Located in several cellular components, including cytoskeleton; glial cell projection; and postsynaptic density. Is expressed in several structures, including gut; nervous system; sensory organ; smooth muscle tissue; and urinary system. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Orthologous to human MAPT (microtubule associated protein tau). [provided by Alliance of Genome Resources, Apr 2022]