Mapt - microtubule-associated protein tau Gene

中文名称：微管相关蛋白 tau

种属: Rattus norvegicus

同用名: Tau; pTau; Mtapt; RNPTAU; MAPT_0N4R

关于 Mapt

功能概要

该基因编码的蛋白可启动多种功能，包括 HSP90 蛋白结合活性；伴侣结合活动；和酶结合活性。参与多个过程，包括响应氧化应激的内在凋亡信号通路； mRNA运输；和长期突触抑制的积极调节。位于多个细胞成分中，包括轴突；质膜的细胞质侧；和神经细胞体。与微管共定位。用于研究脑部疾病（多种）；认知障碍（多种）；肥胖;和 tau 蛋白病（多个）。大脑中动脉梗死的生物标志物。该基因的人类直系同源物与痴呆症有关（多个）；神经退行性疾病（多种）；进行性核上性麻痹；和颞叶癫痫。与人类 MAPT（微管相关蛋白 tau）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including HSP90 protein binding activity; chaperone binding activity; and Enzyme binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; mRNA transport; and positive regulation of long-term synaptic depression. Located in several cellular components, including axon; cytoplasmic side of plasma membrane; and neuronal cell body. Colocalizes with microtubule. Used to study brain disease (multiple); cognitive disorder (multiple); obesity; and tauopathy (multiple). Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); progressive supranuclear palsy; and temporal lobe epilepsy. Orthologous to human MAPT (microtubule associated protein tau). [provided by Alliance of Genome Resources, Apr 2022]