TCL1A 蛋白, Human (His)

TCL1A protein plays a crucial role in cell signaling by actively enhancing the phosphorylation and activation of AKT1, AKT2, and AKT3 while promoting the nuclear translocation of AKT1. Additionally, it aids cell proliferation, stabilizes mitochondrial membrane potential, and promotes cell survival. TCL1A Protein, Human (His) is the recombinant human-derived TCL1A protein, expressed by E. coli , with N-His labeled tag. The total length of TCL1A Protein, Human (His) is 113 a.a., with molecular weight of ~14 kDa.

细胞白血病/淋巴瘤蛋白 1A (TCL1A) 是一种多方面的调节因子，在细胞过程中发挥着关键作用。它通过增强 AKT1、AKT2 和 AKT3 的磷酸化和激活来发挥作用，从而导致它们的核转位。此外，TCL1A 促进细胞增殖、稳定线粒体膜电位并支持细胞存活。TCL1A 作为同二聚体存在，通过 AKT1、AKT2 和 AKT3 的 pleckstrin 同源 (PH) 结构域与 AKT1、AKT2 和 AKT3 相互作用。值得注意的是，TCL1A 与 PNPT1 形成复合物，但这种相互作用并不影响 PNPT1 核酸外切酶活性。TCL1A 的多种分子相互作用和功能含义强调了其在细胞信号传导通路中的重要性，并有助于我们了解其在细胞生长和存活中的作用（参考：提供的信息）。

Human

E. coli

N-His

P56279 (A2-D114)

8115  [NCBI]

AECPTLGEAVTDHPDRLWAWEKFVYLDEKQHAWLPLTIEIKDRLQLRVLLRREDVVLGRPMTPTQIGPSLLPIMWQLYPDGRYRSSDSSFWRLVYHIKIDGVEDMLLELLPDD

Approximately 14 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.