TDGF1 蛋白, Mouse (HEK293, His)

TDGF1, a GPI-anchored protein, participates in Nodal signaling pathways as a coreceptor in cis. Shedding by Tmem8a dynamically regulates Nodal signaling, releasing soluble TDGF1. This shedding mechanism modulates the Nodal pathway and suggests a role in determining the fate of epiblastic cells, particularly in mesoderm formation. TDGF1 also interacts with ACVR1B, emphasizing its importance in cellular responses. TDGF1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TDGF1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TDGF1 Protein, Mouse (HEK293, His) is 125 a.a., with molecular weight of ~19-23 kDa.

TDGF1 是一种糖基磷脂酰肌醇 (GPI) 锚定细胞膜蛋白，积极参与 Nodal 信号传导通路。TDGF1 作为节点辅助受体发挥作用，以顺式方式运作，其细胞相关形式与信号分子协同作用。值得注意的是，Tmem8a 脱落的 TDGF1 通过释放可溶性 TDGF1 动态调节 Nodal 信号传导，使其能够充当邻近细胞的 Nodal 辅助受体。这种脱落机制对节点通路引入了一定程度的调节。TDGF1 参与这些信号级联表明其在决定外胚层细胞（尤其是那些有助于中胚层形成的细胞）的命运方面具有潜在作用。此外，TDGF1 与 1 型激活素受体 ACVR1B 相互作用，进一步凸显了其在介导关键细胞反应中的重要性。

Mouse

HEK293

C-6*His

P51865 (R26-Q150)

21667

RDLAIRDNSIWDQKEPAVRDRSFQFVPSVGIQNSKSLNKTCCLNGGTCILGSFCACPPSFYGRNCEHDVRKEHCGSILHGTWLPKKCSLCRCWHGQLHCLPQTFLPGCDGHVMDQDLKASGTPCQ

Approximately 19-23 kDa due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

<0.1 EU/μg, determined by LAL method.