TFPI 蛋白, Rabbit (HEK293, His)

TFPI Protein inhibits factor X (Xa) directly and, in an Xa-dependent manner, hinders the activity of VIIa/tissue factor, possibly by forming a quaternary complex with Xa, TFPI, VIIa, and tissue factor. This multifunctional protein has antithrombotic properties and associates with lipoproteins in plasma, highlighting its crucial role in regulating the coagulation pathway. TFPI Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived TFPI protein, expressed by HEK293 , with N-10*His labeled tag. The total length of TFPI Protein, Rabbit (HEK293, His) is 276 a.a., with molecular weight of 55 kDa.

TFPI（组织因子途径抑制剂）对因子 X (Xa) 产生直接抑制作用，并以 Xa 依赖性方式阻碍 VIIa/组织因子的活性，可能是通过形成涉及 Xa、TFPI、VIIa 和组织因子。这种多功能蛋白质表现出抗血栓特性，并表现出与血浆中脂蛋白结合的亲和力，突出了其在调节凝血途径复杂动态方面的关键作用。

Measured by its binding ability in a functional ELISA. Immobilized TFPI, Rabbit (HEK293, His) at 1 μg/mL can bind Anti-TFPI recombinant antibody, the EC₅₀ is ≤6 ng/mL.

Rabbit

HEK293

N-10*His

P19761 (A25-T300)

100009401  [NCBI]

AAEEDEEFTNITDIKPPLQKPTHSFCAMKVDDGPCRAYIKRFFFNILTHQCEEFIYGGCEGNENRFESLEECKEKCARDYPKMTTKLTFQKGKPDFCFLEEDPGICRGYITRYFYNNQSKQCERFKYGGCLGNLNNFESLEECKNTCENPTSDFQVDDHRTQLNTVNNTLINQPTKAPRRWAFHGPSWCLPPADRGLCQANEIRFFYNAIIGKCRPFKYSGCGGNENNFTSKKACITACKKGFIPKSIKGGLIKTKRKKKKQPVKITYVETFVKKT

55 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.