Thymidylate 蛋白, Human (HEK293, His)

Thymidylate proteins play a key role in DNA synthesis by catalyzing the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP). This enzymatic process is critical for the production of dTDP, the direct precursor of the DNA building block dTTP. Thymidylate Protein, Human (HEK293, His) is the recombinant human-derived Thymidylate protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Thymidylate Protein, Human (HEK293, His) is 212 a.a., with molecular weight of ~26.0 kDa.

胸苷酸激酶是核苷酸代谢中的必需酶，催化胸苷一磷酸 (dTMP) 磷酸化为胸苷二磷酸 (dTDP)。这种磷酸化反应是脱氧胸苷三磷酸 (dTTP) 生物合成中的关键步骤，而脱氧胸苷三磷酸是 DNA 复制和修复的组成部分。胸苷酸激酶利用 ATP 作为首选磷酰基供体，并且在 Mg(2+) 存在的情况下可促进反应。该酶的活性对于维持平衡的核苷酸库和细胞内 DNA 合成的精确调节至关重要。了解胸苷酸激酶的功能对于阐明 DNA 复制和细胞增殖的复杂过程至关重要。参考资料：所提供的信息基于截至 2022 年 1 月的一般知识，未引用具体参考资料。

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

HEK293

C-6*His

P23919 (M1-K212)

1841  [NCBI]

MAARRGALIVLEGVDRAGKSTQSRKLVEALCAAGHRAELLRFPERSTEIGKLLSSYLQKKSDVEDHSVHLLFSANRWEQVPLIKEKLSQGVTLVVDRYAFSGVAFTGAKENFSLDWCKQPDVGLPKPDLVLFLQLQLADAAKRGAFGHERYENGAFQERALRCFHQLMKDTTLNWKMVDASKSIEAVHEDIRVLSEDAIRTATEKPLGELWK

Approximately 26.0 kDa

Greater than 95% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM PB, 5% Sucrose, 0.05% Tween 80, pH 7.4.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.