TIM-3/HAVCR2 蛋白, Cynomolgus (HEK293, Fc)

TREM-2 Protein binds to DAP10 activates the PI3K signaling pathway. TREM2 signaling leads to downregulated transcription of genes that promote inflammation (Tnf, Il1b, and Nos2), as well as release of cytokines that prevent activation of anti-tumor CD8+ T cells. In addition, it signaling can antagonize TLR expression and signaling, resulting in reduced production of inflammatory cytokines by cultured mouse macrophages. The neuroprotective effects of TREM2 involve not only production of anti-inflammatory cytokines, but also clearance of abnormal proteins and phagocytosis of apoptotic neurons. TIM-3/HAVCR2 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived TIM-3/HAVCR2 protein, expressed by HEK293 , with C-hFc labeled tag.

骨髓细胞表达的触发受体 2 (TREM2) 在巨噬细胞、未成熟单核细胞衍生的树突细胞、破骨细胞和小胶质细胞上表达，这些细胞是中枢神经系统的免疫细胞。TREM2 与 DAP10 的结合会激活 PI3K 信号通路，导致 AP1、NF-κB 和 NFAT 等转录因子的表达。TREM2 信号传导导致促进炎症的基因 (Tnf、Il1b 和 Nos2) 转录下调，并释放阻止抗肿瘤 CD8+ T 细胞激活的细胞因子。此外，它的信号传导可以拮抗 TLR 表达和信号传导，导致培养的小鼠巨噬细胞产生炎症细胞因子的减少。相反，在脂多糖（TLR4 配体）或干扰素 γ (IFNG) 诱导炎症信号传导后，TREM2 表达减少。TREM2的神经保护作用不仅涉及抗炎细胞因子的产生，还涉及异常蛋白的清除和凋亡神经元的吞噬作用。TREM2 在许多肿瘤类型中过度表达并具有抗炎活性^[1][2]。

Cynomolgus

HEK293

C-hFc

G7P6Q7/EHH54703.1 (S22-R201)

101926442

Approximately 60.5&35.8 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.