TL1A/TNFSF15 蛋白, Mouse (Biotinylated, HEK293, His-Avi)

TL1A/TNFSF15 Protein, a receptor for TNFRSF25 and TNFRSF6B, crucially activates NF-kappa-B signaling. It promotes caspase activation for apoptosis and exhibits anti-angiogenic properties, inhibiting vascular endothelial growth and angiogenesis in vitro. The protein contributes to splenocyte alloactivation, emphasizing its significance in immune responses. Functioning as a homotrimer, TL1A/TNFSF15 reflects its structural arrangement in these cellular processes. TL1A/TNFSF15 Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived TL1A/TNFSF15 protein, expressed by HEK293, with N-His, N-Avi labeled tag. The total length of TL1A/TNFSF15 Protein, Mouse (Biotinylated, HEK293, His-Avi) is 192 a.a., with molecular weight of 28-38 kDa.

TL1A/TNFSF15 蛋白作为 TNFRSF25 和 TNFRSF6B 的受体，在介导 NF-κ-B 信号传导的激活中发挥着至关重要的作用。除了通过促进半胱天冬酶的激活参与细胞凋亡之外，TL1A/TNFSF15 还具有抗血管生成特性，可在体外抑制血管内皮生长和血管生成。此外，该蛋白质有助于脾细胞同种异体激活，强调了其在免疫反应中的重要性。TL1A/TNFSF15 作为同源三聚体发挥作用，反映了其在这些细胞过程中的结构排列。

Immobilized Mouse DR3, His Tag at 1 μg/mL(100 μl/well) on the plate. Dose response curve for Biotinylated Mouse TNFSF15, His Tag with the EC₅₀ of ≤16.8 ng/mL determined by ELISA.

Mouse

HEK293

N-His;N-Avi

Q5UBV8 (A61-L252)

326623  [NCBI]

28-38 kDa

Greater than 90% as determined by SEC-HPLC.

无菌粉末

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.