TMEFF1/Tomoregulin-1 蛋白, Mouse (HEK293, Fc)

TMEFF1/Tomoregulin-1 Protein is a transmembrane protein involved in the physiological functions of the central nervous system, embryonic development, and other biological processes. TMEFF1 may inhibit NODAL and BMP signaling during neural patterning. And it may be a tumor suppressor in brain cancers. Additionally, the protein may interact with ST14, implying a molecular association that may contribute to its regulatory and signaling functions. TMEFF1/Tomoregulin-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TMEFF1/Tomoregulin-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TMEFF1/Tomoregulin-1 Protein, Mouse (HEK293, Fc) is 298 a.a., with molecular weight of ~69 kDa.

TMEFF1/Tomoregulin-1 是一种跨膜蛋白，参与中枢神经系统的生理功能、胚胎发育和其他生物过程。TMEFF1 在多种结构中表达，包括消化系统、大脑、神经节、泌尿生殖系统和感觉器官。它可能在神经模式形成过程中抑制 NODAL 和 BMP 信号传导，表明它在控制神经发育的调节过程中的作用。TMEFF1 被认为在脑癌中发挥肿瘤抑制因子的作用，强调了其在减轻神经组织异常细胞生长方面的潜在意义。此外，该蛋白可能与 ST14 相互作用，这意味着分子关联可能有助于其调节和信号传导功能。另外，TMEFF1 作为子宫内膜癌的独立预后因素，促进子宫内膜癌细胞的侵袭和迁移，激活 PI3K/AKT 和 MAPK 信号通路，参与 EMT 的调控^{[1] [2]}。

Mouse

HEK293

C-hFc

EDL02331.1 (L26-V323)

230157  [NCBI]

LFAFCLPGSRASNQPAGGGGDCPGGRGKSNCSELNLRESDIRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKDITVVARGPCYSDNGSGSGEGAEEEGSGAGAHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDVSLLGKKDDGLQYRPDVKDAGDEREDVYIGSHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHV

Approximately 69 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.