TMEM156 蛋白, Human (HEK293, His)

TMEM156 Protein is a member of transmembrane proteins (TMEM) family. The expression levels of TMEM156 correlates with patient survival. TMEM156 is upregulated in tumor tissue. Many genes positively correlated with TMEM156 are involved in multiple immunological processes. Furthermore, genes negatively correlated with TMEM156 are linked with RHO GTPase effectors, which results in a poorer response to receptor activation, thus reducing cancer cell proliferation, survival, and migration. TMEM156 Protein, Human (HEK293, His) is the recombinant human-derived TMEM156 protein, expressed by HEK293 , with C-His labeled tag. The total length of TMEM156 Protein, Human (HEK293, His) is 186 a.a., with molecular weight of ~23 KDa.

跨膜蛋白 156 (TMEM156) 是跨膜蛋白 (TMEM) 家族的成员。TMEM156 的表达水平与患者的生存率相关。TMEM156 在肿瘤组织中表达上调。TMEM156 的表达与免疫、基质和 ESTIMATE 评分显著相关，这表明TMEM156 与肿瘤微环境内的免疫反应之间存在很强的相关性。许多与 TMEM156 呈正相关的基因参与多种免疫过程。此外，与 TMEM156 负相关的基因与 RHO GTPase 效应子相关，导致对受体激活的反应较差，从而降低癌细胞的增殖、存活和迁移^[1]。

Human

HEK293

C-His

AAH30803.1 (K26-S211)

80008  [NCBI]

KTPKERTLELSCLEVCLQSNFTYSLSSLNFSFVTFLQPVRETQIIMRIFLNPSNFRNFTRTCQDITGEFKMCSSCLVCEPKGNMDFISQEQTSKVLIRRGSMEVKANDFHSPCQHFNFSVAPLVDHLEEYNTTCHLKNHTGRSTIMEDEPSKEKSINYTCRIMEYPNDCIHISLHLEMDIKNITCS

Approximately 35-55 kDa due to the glycosylation

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.