TMEM219/IGFBP-3R 蛋白, Human (HEK293, Fc)

The TMEM219/IGFBP-3R protein was identified as an IGFBP3-specific cell death receptor and a potential mediator of caspase-8-dependent apoptosis upon ligand binding. This protein actively binds to IGFBP3, forming a key molecular interaction that may initiate the apoptosis signaling pathway. TMEM219/IGFBP-3R Protein, Human (HEK293, Fc) is the recombinant human-derived TMEM219/IGFBP-3R protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TMEM219/IGFBP-3R Protein, Human (HEK293, Fc) is 166 a.a., with molecular weight of 60-70 kDa.

TMEM219，也称为 IGFBP-3R，是一种细胞死亡受体，对胰岛素样生长因子结合蛋白 3 (IGFBP3) 具有特异性。该受体与其配体 IGFBP3 结合后可能参与介导 caspase-8 依赖性细胞凋亡。TMEM219 和 IGFBP3 之间的直接相互作用强调了其在转导与细胞存活和死亡途径相关的信号中的作用。此外，TMEM219 与 caspase-8 相互作用，进一步表明它可能通过 caspase-8 依赖性途径参与调节细胞凋亡过程。

Human

HEK293

C-hFc

Q86XT9 (S39-R204)

124446  [NCBI]

60-70 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.