2. 重组蛋白
  3. Cytokines and Growth Factors
  4. TNF Superfamily
  5. TNF Receptor Superfamily
  6. Decoy Receptor 1
  7. TNFRSF10C 蛋白, Human (210a.a, HEK293, His)

TNFRSF10C 蛋白, Human (210a.a, HEK293, His)

目录号: HY-P76860
产品使用指南

TNFRSF10C 蛋白是 TRAIL 的一种受体，缺乏细胞质死亡结构域，使其无法诱导细胞凋亡。相反，它可以通过与 TRAIL-R1 和 R2 竞争配体结合来保护细胞，充当诱饵受体并减轻 TRAIL 介导的细胞凋亡。这一独特的功能强调了 TNFRSF10C 在调节细胞对 TRAIL 信号传导反应方面的调控复杂性，表明它参与微调生存和凋亡途径之间的平衡。TNFRSF10C 蛋白, Human (210a.a, HEK293, His) 是重组的 TNFRSF10C 蛋白，由 HEK293 表达，带有 C-His 标签。TNFRSF10C 蛋白, Human (210a.a, HEK293, His) 全长 210 个氨基酸，分子量约为 ~23.6 KDa。

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描述

TNFRSF10C Protein, a receptor for TRAIL, lacks a cytoplasmic death domain, making it unable to induce apoptosis. Instead, it may protect cells by competing with TRAIL-R1 and R2 for ligand binding, acting as a decoy receptor and mitigating TRAIL-mediated apoptosis. This unique feature underscores TNFRSF10C's regulatory complexity in modulating cellular responses to TRAIL signaling, suggesting its involvement in fine-tuning the balance between survival and apoptotic pathways. TNFRSF10C Protein, Human (210a.a, HEK293, His) is the recombinant human-derived TNFRSF10C protein, expressed by HEK293, with C-His labeled tag. The total length of TNFRSF10C Protein, Human (210a.a, HEK293, His) is 210 a.a., with molecular weight of ~23.6 KDa.
研究背景

TNFRSF10C 蛋白作为细胞毒性配体 TRAIL 的受体；然而，它缺乏细胞质死亡结构域，使其无法诱导细胞凋亡。相反，TNFRSF10C 可能通过与 TRAIL-R1 和 R2 竞争与配体的结合，在细胞中发挥保护作用，可能充当诱饵受体，从而减轻 TRAIL 介导的细胞凋亡。这一独特的特征凸显了 TNFRSF10C 在调节细胞对 TRAIL 信号反应的反应中的调节复杂性，并表明它参与微调生存和凋亡途径之间的平衡。
种属

Human
表达系统

HEK293
标签

C-His
蛋白编号

O14798 (A26-P235)
基因 ID
蛋白结构
N-term
TNFRSF10C (A26-P235)
Accession # O14798
His
C-term
同用名
Tumor necrosis factor receptor superfamily member 10C; DcR1; TRAIL-R3; CD263
分子量

Approximately 23.6 kDa.
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

TNFRSF10C Protein, Human (210a.a, HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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