2. Gene
  3. TNFRSF10C - TNF receptor superfamily member 10c Gene

TNFRSF10C - TNF receptor superfamily member 10c Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TNF 受体超家族成员 10c

种属: Homo sapiens

同用名: LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR

基因 ID: 8794 | 基因类型: protein coding

关于 TNFRSF10C

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:23,102,921-23,117,445 (from NCBI)

This gene has 3 transcripts (splice variants), 583 orthologues and 21 paralogues. Broad expression in appendix (RPKM 12.1), bone marrow (RPKM 9.2) and 17 other tissues.

功能概要

由该基因编码的蛋白质是 TNF 受体超家族的成员。该受体包含细胞外 TRAIL 结合域和跨膜域，但没有细胞质死亡域。该受体不能诱导细胞凋亡，并且被认为起拮抗受体的作用，保护细胞免受 TRAIL 诱导的细胞凋亡。该基因被发现是一种 p53 调节的 DNA 损伤诱导基因。在许多正常组织中检测到该基因的表达，但在大多数癌细胞系中未检测到，这可以解释癌细胞对 TRAIL 的凋亡诱导活性的特异性敏感性。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing Apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced Apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most Cancer cell lines, which may explain the specific sensitivity of Cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]

TNFRSF10C 基因产物(1)

mRNA Protein Name
NM_003841.5 NP_003832.3 tumor necrosis factor receptor superfamily member 10C precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TNFRSF10C 蛋白结构

TNFR_c6

TNFR_c6: TNFR/NGFR cysteine-rich region (69 - 109)

TNFR_c6

TNFR_c6: TNFR/NGFR cysteine-rich region (111 - 149)

  • 0
  • 100
  • 200
  • 259 a.a.
蛋白主名 其他名称

tumor necrosis factor receptor superfamily member 10C

TNF-related apoptosis-inducing ligand receptor 3

TNFRSF10C 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TNFRSF10C O14798 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 CYB5R3 Homo sapiens P00387
Validated Y2H
32296183
种属内
TNFRSF10C O14798 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
种属内
TNFRSF10C O14798 SYAP1 Homo sapiens Q96A49
Validated Y2H
32296183
种属内
TNFRSF10C O14798 SYAP1 Homo sapiens Q96A49
Y2H Array
32296183
种属内
TNFRSF10C O14798 SYAP1 Homo sapiens Q96A49
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
种属内
TNFRSF10C O14798 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
种属内
TNFRSF10C O14798 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
种属内
TNFRSF10C O14798 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 TMEM80 Homo sapiens Q96HE8
Validated Y2H
32296183
种属内
TNFRSF10C O14798 KCNJ6 Homo sapiens P48051
Validated Y2H
32296183
种属内
TNFRSF10C O14798 KCNJ6 Homo sapiens P48051
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 KCNJ6 Homo sapiens P48051
Y2H Array
32296183
种属内
TNFRSF10C O14798 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 STOM Homo sapiens P27105
Y2H Array
32296183
种属内
TNFRSF10C O14798 STOM Homo sapiens P27105
Validated Y2H
32296183
种属内
TNFRSF10C O14798 ASZ1 Homo sapiens Q8WWH4
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 ASZ1 Homo sapiens Q8WWH4
Validated Y2H
32296183
种属内
TNFRSF10C O14798 ASZ1 Homo sapiens Q8WWH4
Y2H Array
32296183
种属内
TNFRSF10C O14798 AQP6 Homo sapiens Q13520
Y2H Array
32296183
种属内
TNFRSF10C O14798 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
种属内
TNFRSF10C O14798 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
种属内
TNFRSF10C O14798 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
种属内
TNFRSF10C O14798 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 SLC30A4 Homo sapiens O14863
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 SLC30A4 Homo sapiens O14863
Y2H Array
32296183
种属内
TNFRSF10C O14798 SLC30A4 Homo sapiens O14863
Validated Y2H
32296183
种属内
TNFRSF10C O14798 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
种属内
TNFRSF10C O14798 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
种属内
TNFRSF10C O14798 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 MGST1 Homo sapiens P10620
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 MGST1 Homo sapiens P10620
Validated Y2H
32296183
种属内
TNFRSF10C O14798 MGST1 Homo sapiens P10620
Y2H Array
32296183
种属内
TNFRSF10C O14798 GPR37L1 Homo sapiens O60883
Validated Y2H
32296183
种属内
TNFRSF10C O14798 GPR37L1 Homo sapiens O60883
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 GPR37L1 Homo sapiens O60883
Y2H Array
32296183
种属内
TNFRSF10C O14798 DNAJC1 Homo sapiens Q96KC8
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 DNAJC1 Homo sapiens Q96KC8
Validated Y2H
32296183
种属内
TNFRSF10C O14798 DNAJC1 Homo sapiens Q96KC8
Y2H Array
32296183
种属内
TNFRSF10C O14798 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 SGTA Homo sapiens O43765
Validated Y2H
32296183
种属内
TNFRSF10C O14798 SGTA Homo sapiens O43765
Y2H Array
32296183
种属内
TNFRSF10C O14798 TMEM45B Homo sapiens Q96B21
Validated Y2H
32296183
种属内
TNFRSF10C O14798 TMEM45B Homo sapiens Q96B21
Y2H Array
32296183
种属内
TNFRSF10C O14798 TMEM45B Homo sapiens Q96B21
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 KCNK5 Homo sapiens O95279
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 KCNK5 Homo sapiens O95279
Validated Y2H
32296183
种属内
TNFRSF10C O14798 KCNK5 Homo sapiens O95279
Y2H Array
32296183
种属内
TNFRSF10C O14798 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
种属内
TNFRSF10C O14798 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
种属内
TNFRSF10C O14798 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 PDZK1IP1 Homo sapiens Q13113
Validated Y2H
32296183
种属内
TNFRSF10C O14798 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
种属内
TNFRSF10C O14798 COQ9 Homo sapiens O75208
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 COQ9 Homo sapiens O75208
Validated Y2H
32296183
种属内
TNFRSF10C O14798 COQ9 Homo sapiens O75208
Y2H Array
32296183
种属内
TNFRSF10C O14798 MRPS18B Homo sapiens Q9Y676
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 MRPS18B Homo sapiens Q9Y676
Validated Y2H
32296183
种属内
TNFRSF10C O14798 MRPS18B Homo sapiens Q9Y676
Y2H Array
32296183
种属内
TNFRSF10C O14798 CD79A Homo sapiens P11912
Y2H Array
32296183
种属内
TNFRSF10C O14798 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
种属内
TNFRSF10C O14798 CD79A Homo sapiens P11912
Validated Y2H
32296183
种属内
TNFRSF10C O14798 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
种属内
TNFRSF10C O14798 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
种属内
TNFRSF10C O14798 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TNFRSF10C 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70815 TNFRSF10C Protein, Human (HEK293, His) O14798 (A26-A221) ≥95%
HY-P76860 TNFRSF10C Protein, Human (210a.a, HEK293, His) O14798 (A26-P235) ≥95%

关联疾病

疾病名称 别名
46,Xy Sex Reversal 8

SRXY8

Male Pseudohermaphroditism Due To Deficiency Of Testicular 17,20-Desmolase

Tdd

46,Xy Disorder Of Sex Development Due To Testicular 17,20-Desmolase Deficiency

46xy Sex Reversal 8

46xy Sex Reversal 8, Modifier Of

Male Pseudohermaphroditism: Deficiency Of Testicular 17,20-Desmolase
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Cerebrovascular Benign Neoplasm
Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Myeloma, Multiple

Multiple Myeloma

Plasma Cell Myeloma

Kahler Disease

Myelomatosis

Medullary Plasmacytoma

Multiple Myeloma, Resistance To

Myeloma

Plasma Cell Dyscrasia

Kahler'S Disease

Multiple Myeloma, Susceptibility To

Myeloma - Multiple

Kahler-Bozzolo Disease

Plasma Cell Myelomas

MM

Plasma Cell Neoplasm

Primary Systemic Amyloidosis

Primary Amyloidosis

Immunoglobulin Deposition Disease

Plasmacytic Myeloma

Multiple Myelomata

Multiple Myeloma Nos

Multiple Myeloma Without Mention Of Remission

Monostotic Plasma Cell Myeloma

Mm - [Multiple Myeloma]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14797 TNFRSF10C Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TNFRSF10C MGD MGI:1341090
Rattus norvegicus TNFRSF10C RGD RGD:1586688
Others TNFRSF10C NCBI
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