TNFRSF13B 蛋白, Human (HEK293, Fc)

TNFRSF13B protein is a receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS and exhibits high-affinity binding to both ligands. Its activation stimulates B-cell and T-cell function and modulates humoral immunity through calcineurin-dependent NF-AT activation as well as NF-kappa-B and AP-1 activation. TNFRSF13B Protein, Human (HEK293, Fc) is the recombinant human-derived TNFRSF13B protein, expressed by HEK293 , with C-hFc labeled tag.

TNFRSF13B 蛋白作为 TNFSF13/APRIL 和 TNFSF13B/TALL1/BAFF/BLYS 的受体，表现出与两种配体的高亲和力结合。它的激活导致 NF-AT 的钙调神经磷酸酶依赖性激活，以及 NF-kappa-B 和 AP-1 的激活，从而在刺激 B 细胞和 T 细胞功能以及调节体液免疫方面发挥着至关重要的作用。此外，TNFRSF13B 结合 TRAF2、TRAF5 和 TRAF6，表明其参与多种信号传导途径。值得注意的是，它利用其 C 末端与 CAMLG 的 NH2 末端结构域相互作用。

Human

HEK293

C-hFc

O14836-1 (S2­T166)

23495  [NCBI]

SGLGRSRRGGRSRVDQEERFPQGLWTGVAMRSCPEEQYWDPLLGTCMSCKTICNHQSQRTCAAFCRSLSCRKEQGKFYDHLLRDCISCASICGQHPKQCAYFCENKLRSPVNLPPELRRQRSGEVENNSDNSGRYQGLEHRGSEASPALPGLKLSADQVALVYST

50-54 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.