1. 重组蛋白
  2. Cytokines and Growth Factors
  3. TNF Superfamily
  4. TNF Receptor Superfamily
  5. TACI Protein
  6. TNFRSF13B 蛋白, Human (HEK293, His)

TNFRSF13B 蛋白, Human (HEK293, His)

目录号: HY-P74506
产品使用指南

TNFRSF13B 蛋白是 TNFSF13/APRIL 和 TNFSF13B/TALL1/BAFF/BLYS 的受体,并与两种配体表现出高亲和力结合。它的激活可刺激 B 细胞和 T 细胞功能,并通过钙调神经磷酸酶依赖性 NF-AT 激活以及 NF-kappa-B 和 AP-1 激活调节体液免疫。TNFRSF13B 蛋白, Human (HEK293, His) 是重组的 TNFRSF13B 蛋白,由 HEK293 表达,带有 C-His 标签。

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描述

TNFRSF13B protein is a receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS and exhibits high-affinity binding to both ligands.Its activation stimulates B-cell and T-cell function and modulates humoral immunity through calcineurin-dependent NF-AT activation as well as NF-kappa-B and AP-1 activation.TNFRSF13B Protein, Human (HEK293, His) is the recombinant human-derived TNFRSF13B protein, expressed by HEK293 , with C-His labeled tag.

研究背景

TNFRSF13B 蛋白作为 TNFSF13/APRIL 和 TNFSF13B/TALL1/BAFF/BLYS 的受体,表现出与两种配体的高亲和力结合。它的激活导致 NF-AT 的钙调神经磷酸酶依赖性激活,以及 NF-kappa-B 和 AP-1 的激活,从而在刺激 B 细胞和 T 细胞功能以及调节体液免疫方面发挥着至关重要的作用。此外,TNFRSF13B 结合 TRAF2、TRAF5 和 TRAF6,表明其参与多种信号传导途径。值得注意的是,它利用其 C 末端与 CAMLG 的 NH2 末端结构域相互作用。

种属

Human

表达系统

HEK293

标签

C-His

蛋白编号

O14836-2 (S2-T120)

基因 ID
蛋白结构
N-term
TNFRSF13B (S2-T120)
Accession # O14836-2
His
C-term
同用名
Tumor necrosis factor receptor superfamily member 13B; TACI; CD267; Tnfrsf13b
分子量

18-24 kDa

纯度

Greater than 90% as determined by reducing SDS-PAGE

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

TNFRSF13B Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
TNFRSF13B Protein, Human (HEK293, His)
目录号:
HY-P74506
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