TNF RI/TNFRSF1A 蛋白, Mouse (HEK293, His)

TNFRSF1A (TNF RI) protein has a high ability to bind with tumor necrosis factor-alpha (TNF-α). TNFRSF1A is a STAT3 target gene that regulates the NF-κB pathway. TNFRSF1A activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. TNF RI/TNFRSF1A Protein, Mouse (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region with a His tag at the C-terminus^[1].

TNFRSF1A (TNF RI) 蛋白是一种单通道 I 型膜蛋白，属于肿瘤坏死因子 (TNF) 家族。TNFRSF1A 是 TNF-α 的主要信号受体。TNFRSF1A蛋白是一种多功能细胞因子，几乎所有细胞均合成该蛋白^[1][2]。
不同物种TNFRSF1A的氨基酸序列为非常不同（人类、大鼠和小鼠之间的相似性低于 85%）。
TNFRSF1A 包含一个蛋白质-蛋白质相互作用结构域，称为死亡结构域 (DD)，可以招募其他含有 DD 的蛋白质并将死亡受体与 caspase 偶联激活和凋亡。可溶性和膜结合形式的细胞因子均可激活 TNFRSF1A。TNFRSF1A 通过参与 mTOR、JNK、IKK、caspase 3、MAPK 和 NF-κB 通路诱导细胞炎症损伤和细胞凋亡^[1][3][4]。

Mouse

HEK293

C-His

P25118 (M1-A212)

21937  [NCBI]

Approximately 35 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.

• [1]. Wajant H, et, al. Tumor necrosis factor signaling. Cell Death Differ. 2003 Jan;10(1):45-65.  [Content Brief]

  [2]. Fu Q, et, al. miR-29a up-regulation in AR42J cells contributes to apoptosis via targeting TNFRSF1A gene. World J Gastroenterol. 2016 May 28;22(20):4881-90.  [Content Brief]

  [3]. Zhou S, et, al. Bioinformatics Analysis Identifies TNFRSF1A as a Biomarker of Liver Injury in Sepsis TNFRSF1A is a Biomarker for Septic Liver Injury. Genet Res (Camb). 2022 Oct 15;2022:1493744.  [Content Brief]

  [4]. Egusquiaguirre SP, et, al. The STAT3 Target Gene TNFRSF1A Modulates the NF-κB Pathway in Breast Cancer Cells. Neoplasia. 2018 May;20(5):489-498.  [Content Brief]