2. Gene
  3. Tnfrsf1a - tumor necrosis factor receptor superfamily, member 1a Gene

Tnfrsf1a - tumor necrosis factor receptor superfamily, member 1a Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: FPF; p55; TNF-R; TNFAR; TNFRI; Tnfr1; p55-R; CD120a; TNF-R1; TNFR60; Tnfr-2; TNF-R-I; TNF-R55; TNFRp55; TNF-alphaR1; TNFalpha-R1

基因 ID: 21937 | 基因类型: protein coding

关于 Tnfrsf1a

功能概要

This gene encodes a member of the TNF Receptor Superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, Apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mice lacking a functional copy of this gene exhibit impaired immune function. [provided by RefSeq, Sep 2016]

Tnfrsf1a 基因产物(1)

mRNA Protein Name
NM_011609.4 NP_035739.2 tumor necrosis factor receptor superfamily member 1A precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11374864 MGI
enables signaling receptor activity IDA
IDA: 通过直接分析推断
1647956 MGI
enables tumor necrosis factor receptor activity IDA
IDA: 通过直接分析推断
1647956 MGI
enables tumor necrosis factor receptor activity IGI
IGI: 通过遗传相互作用推断
14985352 MGI
enables tumor necrosis factor receptor activity IMP
IMP: 通过突变表型推断
11588035 MGI
enables tumor necrosis factor receptor activity IPI
IPI: 通过物理相互作用推断
1645445 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in aortic valve development IGI
IGI: 通过遗传相互作用推断
26491108 MGI
acts upstream of or within cell surface receptor signaling pathway IMP
IMP: 通过突变表型推断
9551933 MGI
acts upstream of or within cytokine-mediated signaling pathway IMP
IMP: 通过突变表型推断
11588035 MGI
acts upstream of or within defense response IMP
IMP: 通过突变表型推断
8387893 MGI
acts upstream of or within defense response to bacterium IMP
IMP: 通过突变表型推断
9324362 MGI
acts upstream of or within inflammatory response IMP
IMP: 通过突变表型推断
9551933 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: 通过突变表型推断
17242187 MGI
involved in negative regulation of cardiac muscle hypertrophy IGI
IGI: 通过遗传相互作用推断
26491108 MGI
involved in negative regulation of extracellular matrix constituent secretion IGI
IGI: 通过遗传相互作用推断
26491108 MGI
involved in positive regulation of amide metabolic process IGI
IGI: 通过遗传相互作用推断
14985352 MGI
involved in positive regulation of apoptotic process involved in morphogenesis IGI
IGI: 通过遗传相互作用推断
26491108 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
7525730 MGI
involved in positive regulation of cellular metabolic process IGI
IGI: 通过遗传相互作用推断
14985352 MGI
involved in positive regulation of execution phase of apoptosis IGI
IGI: 通过遗传相互作用推断
10702415 MGI
involved in positive regulation of execution phase of apoptosis IMP
IMP: 通过突变表型推断
10678933 MGI
acts upstream of or within positive regulation of inflammatory response IMP
IMP: 通过突变表型推断
11588035 MGI
involved in positive regulation of lipid metabolic process IGI
IGI: 通过遗传相互作用推断
14985352 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
11588035 MGI
involved in pulmonary valve development IGI
IGI: 通过遗传相互作用推断
26491108 MGI
involved in regulation of membrane lipid metabolic process IGI
IGI: 通过遗传相互作用推断
14985352 MGI
acts upstream of or within regulation of tumor necrosis factor-mediated signaling pathway IGI
IGI: 通过遗传相互作用推断
25220458 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
11588035 MGI
involved in tumor necrosis factor-mediated signaling pathway IGI
IGI: 通过遗传相互作用推断
14985352 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
21410936 MGI
located in membrane raft IDA
IDA: 通过直接分析推断
17010968 MGI
is active in plasma membrane IDA
IDA: 通过直接分析推断
1647956 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tumor necrosis factor receptor superfamily member 1A

TNF receptor alpha chain

TNF-RI

TNF-alpha-R1

TNFR-I

p60

tumor necrosis factor receptor 1

tumor necrosis factor receptor type I

重组 Tnfrsf1a 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72443 TNF RI/TNFRSF1A Protein, Mouse P25118 (I22-A212) ≥95%
HY-P73449 TNF RI/TNFRSF1A Protein, Mouse (HEK293, Fc) P25118 (M1-A212) ≥95%
HY-P73450 TNF RI/TNFRSF1A Protein, Mouse (HEK293, His) P25118 (M1-A212) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-138779 ICCB-19 hydrochloride 99.24% 否
HY-N4323 14-Deoxyandrographolide Inhibitor 99.47% 否
HY-RS14810 TNFRSF1A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tnfrsf1a NCBI NCBI:7132
Macaca fascicularis Tnfrsf1a NCBI NCBI:102135285
Rattus norvegicus Tnfrsf1a NCBI NCBI:25625
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