1. 重组蛋白
  2. Cytokines and Growth Factors
  3. TNF Superfamily
  4. TNF Receptor Superfamily
  5. Decoy Receptor 2
  6. TRAILR4/TNFRSF10D 蛋白, Human (HEK293, Fc)

TRAILR4/TNFRSF10D 蛋白, Human (HEK293, Fc)

目录号: HY-P72439
产品使用指南

TRAILR4/TNFRSF10D 蛋白是 TRAIL 的受体,由于死亡结构域被截短,因此缺乏诱导细胞凋亡的能力。矛盾的是,它不仅不能诱导细胞凋亡,而且还能阻止 TRAIL 介导的细胞凋亡。TRAILR4/TNFRSF10D 蛋白, Human (HEK293, Fc) 是重组的 TRAILR4/TNFRSF10D 蛋白,由 HEK293 表达,带有 C-hFc 标签。TRAILR4/TNFRSF10D 蛋白, Human (HEK293, Fc) 全长 156 个氨基酸,分子量为 50-70 kDa。

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描述

TRAILR4/TNFRSF10D protein is a receptor for TRAIL and lacks the ability to induce apoptosis due to the truncated death domain. Paradoxically, not only does it fail to induce apoptosis, but it also prevents TRAIL-mediated apoptosis. TRAILR4/TNFRSF10D Protein, Human (HEK293, Fc) is the recombinant human-derived TRAILR4/TNFRSF10D protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TRAILR4/TNFRSF10D Protein, Human (HEK293, Fc) is 156 a.a., with molecular weight of 50-70 kDa.

研究背景

TRAILR4/TNFRSF10D 蛋白作为细胞毒性配体 TRAIL 的受体发挥作用,尽管它包含截短的死亡结构域,使其无法诱导细胞凋亡。矛盾的是,TRAILR4/TNFRSF10D 不仅不能诱导细胞凋亡,而且还对 TRAIL 介导的细胞凋亡发挥保护作用。关于其激活 NF-kappa-B 通路的能力存在相互矛盾的信息,一些研究表明它不能诱导该通路,而其他研究则认为它具有激活 NF-kappa-B 的能力。TRAILR4/TNFRSF10D 与 TRAIL 相互作用的双重性质,既作为受体又作为抗凋亡的保护因子,强调了其在细胞对 TRAIL 信号传导反应中调节功能的复杂性。

种属

Human

表达系统

HEK293

标签

C-hFc

蛋白编号

Q9UBN6 (A56-H211)

基因 ID
蛋白结构
N-term
TRAIL (A56-H211)
Accession # Q9UBN6
hFc
C-term
同用名
Tumor necrosis factor receptor superfamily member 10D; DcR2; TRAIL receptor 4; TRAIL-R4; CD264; TNFRSF10D; DCR2; TRAILR4; TRUNDD
氨基酸序列

ATIPRQDEVPQQTVAPQQQRRSLKEEECPAGSHRSEYTGACNPCTEGVDYTIASNNLPSCLLCTVCKSGQTNKSSCTTTRDTVCQCEKGSFQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIKCKNESAASSTGKTPAAEETVTTILGMLASPYH

分子量

50-70 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

TRAILR4/TNFRSF10D Protein, Human (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
TRAILR4/TNFRSF10D Protein, Human (HEK293, Fc)
目录号:
HY-P72439
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