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  2. TNFRSF10D - TNF receptor superfamily member 10d Gene

TNFRSF10D - TNF receptor superfamily member 10d Gene

中文名称:TNF 受体超家族成员 10d

种属: Homo sapiens

同用名: DCR2; CD264; TRUNDD; TRAILR4; TRAIL-R4

基因 ID: 8793 | 基因类型: protein coding

关于 TNFRSF10D

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:23,135,588-23,164,027 (from NCBI)

This gene has 1 transcript (splice variant), 587 orthologues and 21 paralogues. Ubiquitous expression in gall bladder (RPKM 5.6), colon (RPKM 4.7) and 24 other tissues.

功能概要

由该基因编码的蛋白质是 TNF 受体超家族的成员。该受体包含细胞外 TRAIL 结合结构域、跨膜结构域和截短的细胞质死亡结构域。该受体不诱导细胞凋亡,并且已显示在 TRAIL 诱导的细胞凋亡中发挥抑制作用。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce Apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell Apoptosis. [provided by RefSeq, Jul 2008]

TNFRSF10D 基因产物(1)

mRNA Protein Name
NM_003840.5 NP_003831.2 tumor necrosis factor receptor superfamily member 10D precursor

TNFRSF10D 蛋白结构

TNFR_c6

TNFR_c6: TNFR/NGFR cysteine-rich region (99 - 139)

TNFR_c6

TNFR_c6: TNFR/NGFR cysteine-rich region (141 - 180)

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  • 386 a.a.
蛋白主名 其他名称

tumor necrosis factor receptor superfamily member 10D

TNF receptor-related receptor for TRAIL

重组 TNFRSF10D 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72439 TRAILR4/TNFRSF10D Protein, Human (HEK293, Fc) Q9UBN6 (A56-H211) ≥95%
HY-P76863 TRAILR4/TNFRSF10D Protein, Human (HEK293, His) Q9UBN6 (A56-H211) ≥95%
HY-P78221 TRAILR4/TNFRSF10D Protein, Human (Biotinylated, HEK293, His-Avi) Q9UBN6 (A56-H211) ≥95%
HY-P78531 TRAILR4/TNFRSF10D Protein, Human (HEK293, His-Avi) Q9UBN6 (A56-H211) ≥95%

关联疾病

疾病名称 别名
46,Xy Sex Reversal 8

SRXY8

Male Pseudohermaphroditism Due To Deficiency Of Testicular 17,20-Desmolase

Tdd

46,Xy Disorder Of Sex Development Due To Testicular 17,20-Desmolase Deficiency

46xy Sex Reversal 8

46xy Sex Reversal 8, Modifier Of

Male Pseudohermaphroditism: Deficiency Of Testicular 17,20-Desmolase

Trigonitis

Bladder Trigonitis

Pseudomembranous Trigonitis

Osteogenic Sarcoma

Osteosarcoma

OSRC

Osteosarcoma, Somatic

Neoplasms, Bone Tissue

Bone Tissue Neoplasm

Osteoid Sarcoma

Skeletal Sarcoma

Osteosarcoma Of Bone

Bone Sarcoma

Li-Fraumeni Syndrome 1

Lfs1

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus TNFRSF10D MGD MGI:1341090
Macaca mulatta TNFRSF10D NCBI NCBI:716901