1. 重组蛋白
  2. Cytokines and Growth Factors
  3. TNF Superfamily
  4. TNF Receptor Superfamily
  5. Decoy Receptor 2
  6. TRAILR4/TNFRSF10D 蛋白, Rhesus Macaque (HEK293, His)

TRAILR4/TNFRSF10D 蛋白, Rhesus Macaque (HEK293, His)

目录号: HY-P76865
COA 产品使用指南

TRAILR4/TNFRSF10D 蛋白是 TRAIL 的一种受体。矛盾的是,它不仅不能诱导细胞凋亡,而且还能防止 TRAIL 介导的细胞凋亡。关于其在激活 NF-kappa-B 通路中的作用存在相互矛盾的报道。TRAILR4 与 TRAIL 相互作用的双重性质,既作为受体又作为保护因子,凸显了其在细胞对 TRAIL 信号传导反应中调节功能的复杂性。TRAILR4/TNFRSF10D 蛋白, Rhesus Macaque (HEK293, His) 是重组的 TRAILR4/TNFRSF10D 蛋白,由 HEK293 表达,带有 C-His 标签。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

SPR 检测服务   重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
Free Sample   Apply now  
2 μg ¥300 In-stock
10 μg ¥850 In-stock
50 μg ¥2375 In-stock
100 μg ¥3800 In-stock
> 100 μg   询价  

* Please select Quantity before adding items.

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

TRAILR4/TNFRSF10D Protein , a receptor for TRAIL. Paradoxically, it not only fails to induce apoptosis but also protects against TRAIL-mediated apoptosis. Conflicting reports exist about its role in activating the NF-kappa-B pathway. The dual nature of TRAILR4 in interacting with TRAIL, both as a receptor and a protective factor, highlights the complexity of its regulatory functions in cellular responses to TRAIL signaling. TRAILR4/TNFRSF10D Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived TRAILR4/TNFRSF10D protein, expressed by HEK293 , with C-His labeled tag.

研究背景

TRAILR4/TNFRSF10D 作为细胞毒性配体 TRAIL 的受体发挥作用,由于它包含截短的死亡结构域,使其无法诱导细胞凋亡。矛盾的是,TRAILR4 不仅不能诱导细胞凋亡,而且还对 TRAIL 介导的细胞凋亡发挥保护作用。关于其激活 NF-kappa-B 通路的能力存在相互矛盾的信息,一些研究表明它不能诱导该通路,而其他研究则认为它具有激活 NF-kappa-B 的能力。TRAILR4 与 TRAIL 相互作用的双重性质,既作为受体,又作为抗凋亡的保护因子,强调了其在细胞对 TRAIL 信号传导反应中调节功能的复杂性[1][2][3]

生物活性

Measured by its ability to inhibit TRAIL-mediated cytotoxicity using L-929 mouse fibroblast cells treated with TRAIL. The ED50 for this effect is 6.265 ng/mL in the presence of 20 ng/mL of rhTRAIL, corresponding to a specific activity is 1.60 ×105 units/mg.

  • Measured by its ability to inhibit TRAIL-mediated cytotoxicity using L-929 mouse fibroblast cells treated with TRAIL. The ED50 for this effect is 6.265 ng/mL in the presence of 20 ng/mL of rhTRAIL, corresponding to a specific activity is 1.60 ×105 units/mg.
种属

Rhesus Macaque

表达系统

HEK293

标签

C-6*His

蛋白编号

XP_001107922 (A56-L206)

基因 ID
蛋白结构
N-term
TRAIL (A56-L206)
Accession # XP_001107922
His
C-term
同用名
Tumor necrosis factor receptor superfamily member 10D; DcR2; TRAIL-R4; CD264; TRUNDD
氨基酸序列

ATISRKDEVPLPPVASKQQRRSLEAECPAGFHRSEHTGACNPCTEGVDYTIASNNLPSCLLCTVCKSGQTNTSSCTTTRDTVCQCEKGSFQDANSPEMCRKCSTGCPRGMIKVSDCTPWSDINCSASAASSTGKTPAAEDTVPTSLGTPDL

分子量

Approximately 22-32 kDa due to the glycosylation.

纯度
  • Greater than 95% as determined by reducing SDS-PAGE.
性状

无菌粉末

组分

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料

TRAILR4/TNFRSF10D Protein, Rhesus Macaque (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
TRAILR4/TNFRSF10D Protein, Rhesus Macaque (HEK293, His)
目录号:
HY-P76865
需求量: