TREM-2 蛋白, Cynomolgus (HEK293, His)

TREM-2 protein forms a signaling complex with TYROBP, activates cells upon ligand binding, and acts as a receptor for amyloid beta, lipoproteins, and apolipoproteins. It promotes their uptake by microglia, triggering activation, proliferation, migration, apoptosis and cytokine expression. TREM-2 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TREM-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TREM-2 Protein, Cynomolgus (HEK293, His) is 156 a.a., with molecular weight of 28-40 kDa.

TREM-2 蛋白与 TYROBP 形成受体信号传导复合物，在配体结合后介导信号传导和细胞激活。它作为淀粉样蛋白 42 的受体，促进小胶质细胞对其的摄取和降解，从而导致小胶质细胞激活、增殖、迁移、凋亡和细胞因子表达。此外，TREM-2 作为脂蛋白颗粒和载脂蛋白的受体，增强它们在小胶质细胞中的摄取。它结合磷脂并调节小胶质细胞增殖、凋亡神经元的吞噬作用以及对氧化应激的反应。此外，TREM-2 抑制 PI3K 和 NF-kappa-B 信号传导，在氧化应激过程中促进抗凋亡 NF-kappa-B 信号传导，并在小胶质细胞 MTOR 激活和代谢中发挥作用。它涉及小胶质细胞数量与年龄相关的变化，并触发巨噬细胞和树突状细胞的免疫反应。TREM-2 还介导细胞因子诱导的多核巨细胞形成，并参与破骨细胞分化。该蛋白与 TYROBP 相互作用，这种相互作用对于稳定 TREM-2 C 末端片段至关重要。

Cynomolgus

HEK293

C-6*His

XP_005553122.1 (H19-S174)

102133279  [NCBI]

HNTTVFQGVEGQSLQVSCPYDSMKHWGRRKAWCRQLGEKGPCQRVVSTHNLWLLSFLRRRNGSTAITDDTLGGTLTITLRNLQPHDAGFYQCQSLHGSEADTLRKVLVEVLADPLDHRDAGDLWVPGESESFEDAHVEHSISRSLLEGEIPFPPTS

28-40 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.