1. 重组蛋白
  2. Receptor Proteins
  3. TREML1 蛋白, Mouse (HEK293, hFc)

TREML1 蛋白, Mouse (HEK293, hFc)

目录号: HY-P700836
产品使用指南

TREML1 是髓样细胞上表达的触发受体 1,通过接头蛋白 DAP12 激活髓细胞。TREML1 可以促进 Aβ 的小胶质细胞吞噬,与 AD 的免疫反应有关。TREML1 蛋白, Mouse (HEK293, hFc) 是重组的 TREML1 蛋白,由 HEK293 表达,带有 C-hFc 标签。

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描述

TREML1 is a trigger receptor 1 expressed on myeloid cells that activates myeloid cells via the adaptor protein DAP12. TREML1 promotes microglial phagocytosis of Aβ and is associated with the immune response to AD. TREML1 Protein, Mouse (HEK293, hFc) is the recombinant mouse-derived TREML1 protein, expressed by HEK293 , with C-hFc labeled tag.

研究背景

TREML1 是髓样细胞上表达的触发受体 1,单核/巨噬细胞和血液中性粒细胞是人 TREML1 在先天反应中的主要效应细胞。TREML1 通过接头蛋白 DAP12 激活髓细胞。TREMs 家族不仅参与小胶质细胞吞噬和淀粉样蛋白清除的调控,在 AD 的神经炎症反应中也起着不可或缺的作用。TREML1 可以促进 Aβ 的小胶质细胞吞噬,与 AD 的免疫反应有关。

种属

Mouse

表达系统

HEK293

标签

C-hFc

蛋白编号

Q8K558-2/AAL85488.1 (D21-Q175)

基因 ID
蛋白结构
N-term
TREML1 (D21-Q175)
Accession # Q8K558-2/AAL85488.1
hFc
C-term
同用名
TLT-1; TREML1; TLT1; Trem-like transcript 1; UNQ1825/PRO3438; dJ238O23.3; GLTL1825; MGC119173; PRO3438
分子量

50-55 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

TREML1 Protein, Mouse (HEK293, hFc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
TREML1 Protein, Mouse (HEK293, hFc)
目录号:
HY-P700836
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