1. 重组蛋白
  2. Enzymes & Regulators Ubiquitin Related Proteins
  3. Transferases (EC 2) Ubiquitin Enzymes
  4. E3 Ligases
  5. TRIM/RBCC Proteins
  6. TRIM2 蛋白, Human

TRIM2 蛋白, Human

目录号: HY-P701503
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TRIM2 是一种 UBE2D1 依赖性 E3 泛素蛋白连接酶,介导 NEFL 和磷酸化 BCL2L11 的泛素化。除了其连接酶作用外,TRIM2 还具有神经保护功能并有助于神经元快速缺血耐受。它至关重要地参与抗病毒免疫,限制新世界沙粒病毒感染。这凸显了 TRIM2 在泛素介导的蛋白质降解之外的细胞过程中的多方面参与。TRIM2 蛋白, Human 是重组的 TRIM2 蛋白,由 E. coli 表达,不带标签。TRIM2 蛋白, Human 全长 743 个氨基酸。

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描述

TRIM2, an UBE2D1-dependent E3 ubiquitin-protein ligase, mediates the ubiquitination of NEFL and phosphorylated BCL2L11. Beyond its ligase role, TRIM2 has neuroprotective functions and aids neuronal rapid ischemic tolerance. It crucially participates in antiviral immunity, restricting New World arenavirus infection. This highlights TRIM2's multifaceted involvement in cellular processes beyond ubiquitin-mediated protein degradation. TRIM2 Protein, Human is the recombinant human-derived TRIM2 protein, expressed by E. coli , with tag free. The total length of TRIM2 Protein, Human is 743 a.a., .

研究背景

TRIM2 是一种 UBE2D1 依赖性 E3 泛素蛋白连接酶,充当 NEFL 和磷酸化 BCL2L11 泛素化的介体。除了在泛素连接酶活性中发挥作用外,TRIM2 还具有神经保护功能,并可能有助于神经元快速缺血耐受。此外,它在抗病毒免疫中发挥着至关重要的作用,并作为新世界沙粒病毒感染的限制剂,强调其在泛素介导的蛋白质降解之外的细胞过程中的多方面参与。

种属

Human

表达系统

E. coli

标签

Tag Free

蛋白编号

Q9C040 (A2-Q744)

基因 ID

23321

蛋白结构
N-term
TRIM2 (A2-Q744)
Accession # Q9C040
C-term
同用名
TRIM2; Tripartite motif-containing protein 2; E3 ubiquitin-protein ligase TRIM2; RING finger protein 86; RING-type E3 ubiquitin transferase TRIM2
纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

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Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
TRIM2 Protein, Human
目录号:
HY-P701503
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