TRIM21 蛋白, Human (P.pastoris, His)

TRIM21 Protein, an E3 ubiquitin ligase, plays a vital role in the immune response by targeting intracellular pathogens for degradation. It is involved in the recognition and clearance of viral particles. The therapeutic potential of targeting TRIM21 Protein in infectious diseases and its role in host defense make it a subject of interest in biomedical research. TRIM21 Protein, Human (P.pastoris, His) is the recombinant human-derived TRIM21 protein, expressed by P. pastoris , with N-His labeled tag. The total length of TRIM21 Protein, Human (P.pastoris, His) is 475 a.a., with molecular weight of ~56.2 kDa.

所描述的蛋白质参与各种细胞过程和途径。它与 VCP 介导的 ERAD 途径有关，该途径负责消除内质网中错误折叠的蛋白质。它促进 IRF8 泛素化，增强其刺激巨噬细胞中细胞因子基因转录的能力。它还在调节细胞周期进程中发挥作用。

Human

P. pastoris

N-His

P19474 (1M-475Y)

6737  [NCBI]

MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVNNLKEISQEAREGTQGERCAVHGERLHLFCEKDGKALCWVCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRRKQELAEKLEVEIAIKRADWKKTVETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISELDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGKEAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTYPQTPLHLQVPPCQVGIFLDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQGSTDY

Approximately 56.2 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized after extensive dialysis against solution in 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.