1. Gene
  2. TRIM21 - tripartite motif containing 21 Gene

TRIM21 - tripartite motif containing 21 Gene

中文名称:含三方基序 21

种属: Homo sapiens

同用名: SSA; RO52; SSA1; RNF81; Ro/SSA

基因 ID: 6737 | 基因类型: protein coding

关于 TRIM21

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:4,384,897-4,393,702 (from NCBI)

This gene has 2 transcripts (splice variants), 96 orthologues and 80 paralogues. Ubiquitous expression in spleen (RPKM 15.5), appendix (RPKM 13.2) and 24 other tissues.

功能概要

该基因编码三联基序 (TRIM) 家族的成员。 TRIM 基序包括三个锌结合域、一个 RING、一个 B-box 类型 1 和一个 B-box 类型 2,以及一个卷曲螺旋区域。编码的蛋白质是 RoSSA 核糖核蛋白的一部分,它包括一个多肽和四个小 RNA 分子之一。 RoSSA 粒子定位于细胞质和细胞核。 RoSSA 与干燥综合征和系统性红斑狼疮患者的自身抗原相互作用。已经描述了该基因的可变剪接转录本变体,但仅确定了一个的全长性质。[RefSeq 提供,2008 年 7 月]

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

TRIM21 基因产物(1)

mRNA Protein Name
NM_003141.4 NP_003132.2 E3 ubiquitin-protein ligase TRIM21
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
17156811 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
8666824 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
23077300 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
26342464 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
16297862 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in innate immune response IDA
IDA: 通过直接分析推断
18248090 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: 通过直接分析推断
19675099 GOA
involved in negative regulation of innate immune response IDA
IDA: 通过直接分析推断
26342464 GOA
involved in negative regulation of protein deubiquitination IMP
IMP: 通过突变表型推断
16472766 GOA
involved in negative regulation of viral transcription IDA
IDA: 通过直接分析推断
18248090 GOA
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
23077300 GOA
involved in positive regulation of autophagy IMP
IMP: 通过突变表型推断
26347139 GOA
involved in positive regulation of cell cycle IMP
IMP: 通过突变表型推断
16880511 GOA
involved in positive regulation of protein binding IMP
IMP: 通过突变表型推断
26342464 GOA
involved in proteasomal protein catabolic process IDA
IDA: 通过直接分析推断
36359729 GOA
involved in protein K27-linked ubiquitination IDA
IDA: 通过直接分析推断
26342464 GOA
involved in protein K48-linked ubiquitination IDA
IDA: 通过直接分析推断
36359729 GOA
involved in protein K6-linked ubiquitination IDA
IDA: 通过直接分析推断
36426955 GOA
involved in protein K63-linked ubiquitination IDA
IDA: 通过直接分析推断
36692217 GOA
involved in protein K63-linked ubiquitination IMP
IMP: 通过突变表型推断
26342464 GOA
involved in protein autoubiquitination IDA
IDA: 通过直接分析推断
16880511 GOA
involved in protein destabilization IMP
IMP: 通过突变表型推断
16880511 GOA
involved in protein monoubiquitination IDA
IDA: 通过直接分析推断
16297862 GOA
involved in protein polyubiquitination IDA
IDA: 通过直接分析推断
16297862 GOA
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
16472766 GOA
involved in pyroptotic inflammatory response IDA
IDA: 通过直接分析推断
36426955 GOA
involved in response to type II interferon IDA
IDA: 通过直接分析推断
26347139 GOA
involved in stress granule disassembly IDA
IDA: 通过直接分析推断
36692217 GOA
involved in suppression of viral release by host IDA
IDA: 通过直接分析推断
18248090 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SCF ubiquitin ligase complex IDA
IDA: 通过直接分析推断
16880511 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
16316627 GOA
is active in cytoplasmic stress granule IDA
IDA: 通过直接分析推断
36692217 GOA
located in nucleus IDA
IDA: 通过直接分析推断
18845142 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TRIM21 蛋白结构

zf-C3HC4_4

zf-C3HC4_4: zinc finger of C3HC4-type, RING (16 - 54)

zf-B_box

zf-B_box: B-box zinc finger (88 - 128)

PRY

PRY: SPRY-associated domain (289 - 337)

SPRY

SPRY: SPRY domain (339 - 455)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 475 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase TRIM21

52 kDa Ro protein

重组 TRIM21 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71791 TRIM21 Protein, Human (P.pastoris, His) P19474 (1M-475Y) ≥95%

关联疾病

疾病名称 别名
Lupus Erythematosus

Lupus

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus, Systemic

Subacute Cutaneous Lupus

Le - [Lupus Erythematosus]

Sjogren Syndrome

Sicca Syndrome

Sjogren'S Syndrome

Sjögren Syndrome

Sjogren-Gougerot Syndrome

Keratoconjunctivitis Sicca

Sjögren'S Syndrome

Xerodermosteosis

Dacryosialoadenopathia Atrophicans

Gougerot-Houwer-Sjogren Syndrome

Gougerot-Sjogren Syndrome

Keratoconjunctivitis Sicca-Xerostomia

Secreto-Inhibitor-Xerodermostenosis

Primary Sjogren Syndrome

Primary Sjogren-Gougerot Syndrome

Sjogrens Syndrome Primary

Sjogrens Syndrome

Dry Eye Syndromes

Heart Block, Congenital

Congenital Heart Block

Heart Block Congenital

Congenital Atrioventricular Block

Subacute Cutaneous Lupus Erythematosus

Lupus Erythematosus Cutaneous Subacute

Lupus Erythematosus, Subacute Cutaneous

Sacle - [Subacute Cutaneous Lupus Erythematosus]

Scle - [Subacute Cutaneous Lupus Erythematosus]

Third-Degree Atrioventricular Block

Third Degree Atrioventricular Block

Complete Atrioventricular Block

Complete Av Block

Third-Degree Block

Complete Atrioventricular Heart Block

Complete Heart Block

Third Degree Atrioventricular Heart Block

Third Degree Heart Block

Complete Heart Block Nos

Chb - [Complete Heart Block]

Idioventricular Rhythm

Av - [Atrioventricular] Block, Complete

Myositis

Idiopathic Inflammatory Myopathy

Idiopathic Inflammatory Myositis

Iim

Imm

Idiopathic Inflammatory Myopathies

Myopathy, Familial Idiopathic Inflammatory

Inflammatory Disorder Of Muscle

Idiopathic Inflammatory Myopathy, Familial

Inflammatory Myopathy, Idiopathic

Myopathies Idiopathic Inflammatory

Familial Idiopathic Inflammatory Myopathy

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Second-Degree Atrioventricular Block

Second-Degree Heart Block

Second Degree Atrioventricular Block

Second Degree Atrioventricular Heart Block

Second Degree Heart Block

Incomplete Atrioventricular Block, Second Degree Nos

Second-Degree Block, Type 1 And 2

Atrioventricular Block, Type 1 And 2

Second Degree Incomplete Atrioventricular Block

Av - [Atrioventricular] Block 2nd

Lymphoid Interstitial Pneumonia

Lymphocytic Interstitial Pneumonia

Lip Disease

Lip Diseases

LIP

Disease Of Lips

Xerophthalmia

Conjunctival Xerosis

Autoimmune Disease Of Exocrine System
Systemic Scleroderma

Scleroderma

Progressive Systemic Sclerosis

Systemic Sclerosis

Scleroderma, Systemic

Scleroderma Syndrome

Dermatosclerosis

Familial Progressive Scleroderma

Progressive Scleroderma

Scleroderma Disease

Scleroderma, Localized

Diffuse Scleroderma

Scleroderma, Familial Progressive

Drug-Induced Lupus Erythematosus

Dile

Dil

Drug-Induced Systemic Lupus Erythematosus

Cutaneous Lupus Erythematosus

Lupus Erythematosus, Cutaneous

Lupus Erythematosus Cutaneous

Lacrimal Apparatus Disease

Lacrimal Apparatus Diseases

Antisynthetase Syndrome

As Syndrome

Anti-Jo1 Syndrome

Keratoconjunctivitis
Phototoxic Dermatitis

Dermatitis, Phototoxic

Photosensitisation Reaction

Photosensitive Dermatitis

Photosensitiveness

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome

Chromosome 11p11.2 Deletion Syndrome

Pss

11p11.2 Deletion

P11pds

Defect11 Syndrome

Deletion Of Chromosome 11p11.2

POSHS

Conjunctival Vascular Disease

Vascular Abnormalities Of Conjunctiva

Conjunctival Vascular Abnormality

Vascular Abnormality Of Conjunctiva

Lymphocytic Choriomeningitis

Lcm

Lymphocytic Meningitis

Lymphocytic Choriomeningitis Virus Encephalomyelitis

Lymphocytic Meningoencephalitis

Non-Arthropod Borne Lymphocytic Choriomeningitis

Lcm - [Lymphocytic Choriomeningitis]

Benign Lymphocytic Meningitis

Meningitis Due To Lymphocytic Choriomeningitis Virus

Parotid Disease

Parotid Diseases

Nonspecific Interstitial Pneumonia

Nsip

Non-Specific Interstitial Pneumonia

Non-Specific Idiopathic Interstitial Pneumonia

Non-Specific Interstitial Pneumonia Nos

Mononeuritis Multiplex
Diffuse Infiltrative Lymphocytosis Syndrome
Sialadenitis

Sialoadenitis

Adenitis, Salivary Gland

Salivary Gland Inflammation

Salivary Gland Adenitis

Sialitis

Inflammation Of Salivary Gland

Inflammation Of Salivary Duct Or Gland

Salivary Glandular Adenitis

Sialoangiitis

Sialoangitis

Sialodochitis

Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos

Dry Eye Syndrome

Dry Eye Syndromes

Dry Eye Disease

Tear Film Insufficiency

Xerophthalmia

Transient Neonatal Thrombocytopenia
Transient Neonatal Neutropenia
Endocardial Fibroelastosis

Endomyocardial Fibroelastosis

Elastomyofibrosis

EFE

Efe - [Endocardial Fibroelastosis]

Primary Endocardial Fibroelastosis

Fibroelastosis Cordis

Fetal Endocarditis

Fibroelastosis

Congenital Endocardial Fibroelastosis

Congenital Valvular Endocarditis

Mononeuritis Of Upper Limb And Mononeuritis Multiplex
Adult Dermatomyositis

Adult Onset Dermatomyositis

Adult Type Dermatomyositis

Keratoconjunctivitis Sicca

Kcs

Dry Eye Syndromes

Keratitis Sicca

Xerophthalmia

Childhood Type Dermatomyositis

Juvenile Dermatomyositis

Juvenile Dm

Childhood Dermatomyositis

Amyopathic Dermatomyositis

Adm

Dermatomyositis Sine Myositis

Dermatomyositis, Childhood Type

Malignant Secondary Hypertension
Atrioventricular Block

Av Block

Libman-Sacks Endocarditis

Libmann-Sachs, Endocarditis In Systemic Lupus Erythematosus

Idiopathic Interstitial Pneumonia

Hamman-Rich Syndrome

Diffuse Idiopathic Pulmonary Fibrosis

Idiopathic Fibrosing Alveolitis

Ipf

Idiopathic Interstitial Pneumonias

Idiopathic Interstitial Pneumonia, Not Otherwise Specified

Pulmonary Fibrosis

Aphthous Stomatitis

Oral Ulcer

Canker Sore

Aphtha

Aphthous Ulceration

Oral Aphthae

Oral Aphthous Ulcer

Canker Sores

Stomatitis, Aphthous

Minor Oral Aphthous Ulceration

Chromosomal Deletion Syndrome
Mononeuropathy

Mononeuropathies

Dacryoadenitis

Dacryocystitis

Mikulicz Disease

Igg4-Related Dacryoadenitis And Sialadenitis

Mikulicz'S Disease

Chronic Dacryoadenitis And Sialadenitis

Mikulicz Syndrome

Mikulicz' Disease

Axonal Neuropathy
Salivary Gland Disease

Salivary Gland Disorders

Salivary Gland Diseases

Non-Neoplastic Salivary Gland Disease

Non-Neoplastic Salivary Gland Disorder

Disorder Of Salivary Gland

Lesion Of Salivary Gland Nos

Exanthem

Exanthema

Rash

Rashes

Parotitis
Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease

First-Degree Atrioventricular Block

First Degree Atrioventricular Block

First Degree Heart Block

Incomplete Atrioventricular Block, First Degree

First Degree Atrioventricular Heart Block

Polyclonal Hypergammaglobulinemia

Polyclonal Gammopathy

Diffuse Scleroderma

Diffuse Systemic Sclerosis

Systemic Sclerosis, Diffuse

Scleroderma, Diffuse

Systemic Scleroderma

Progressive System Sclerosis

Dyskinesia Of Esophagus

Esophageal Motility Disorders

Dyskinesia Of Oesophagus

Esophageal Dysmotility

Esophageal Motility Disorder

Oesophageal Dysmotility

Oesophageal Motor Disorder

Esophageal Spasm

Limited Scleroderma

Limited Cutaneous Systemic Sclerosis

Limited Systemic Sclerosis

Systemic Sclerosis Sine Scleroderma

Crest Syndrome

Limited Cutaneous Systemic Scleroderma

Scleroderma, Limited

Systemic Sclerosis, Limited

Progressive Systemic Sclerosis Sine Scleroderma

Scleroderma, Sine

Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome

Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

Raynaud Disease

Raynaud'S Disease

Raynaud Phenomenon

Raynaud'S Syndrome

Raynaud'S

Cold Fingers, Hereditary

Raynaud'S Phenomenon

Raynaud'S Disease/Phenomenon

Raynauds Syndrome

Raynauds Phenomenon

Secondary Raynaud'S Phenomenon

Raynaud Syndrome

Transverse Myelitis

Myelitis Transverse

Myelitis, Transverse

Collagen Disease

Collagen Diseases

Collagen Disorder

Temporal Arteritis

Polymyalgia Rheumatica

Giant Cell Arteritis

Cranial Arteritis

Horton Disease

Gca

Horton'S Disease

Rhizomelic Pseudopolyarthritis

Arteritis Cranialis

Arteritis Temporalis

Horton'S Arteritis

Horton'S Giant Cell Arteritis

Horton'S Temporal Arteritis

Horton'S Syndrome

Gca - [Giant Cell Arteritis]

Senile Arthritis

Polymyalgia Arteritica

Pmr - [Polymyalgia Rheumatica]

Forestier-Certonciny Syndrome

Rheumatic Polymyalgia

Polymyalgia

Telangiectasis

Telangiectasia

Autoimmune Disease Of Musculoskeletal System
Punctate Epithelial Keratoconjunctivitis

Punctate Keratitis

Thygeson Superficial Punctate Keratitis

Thygeson'S Superficial Punctate Keratitis

Thygeson Superficial Punctate Keratopathy

Punctate Epithelial Keratitis

Pericardium Disease
Hypersensitivity Reaction Type Iv Disease

Immunoproliferative Disorders

Immunoproliferative Disease

Autoimmune Disease Of Cardiovascular System
Chromosomal Disease

Chromosomal Disorders

Congenital Chromosomal Disease

Heart Conduction Disease

Conduction Disorder Of The Heart

Heart Rhythm Disease

Muscle Tissue Disease
Hyperlipoproteinemia, Type V

Hyperlipoproteinemia Type V

Hyperchylomicronemia, Late-Onset

Familial Type 5 Hyperlipoproteinemia

Hyperchylomicronemia With Hyperprebetalipoproteinemia, Familial

Hyperlipidemia, Type V

Hyperlipemia, Mixed

Hyperlipemia, Combined Fat And Carbohydrate-Induced

Familial Hyperlipoproteinemia Type V

Fredrickson Type V Lipaemia

Hyperlipoproteinemia Type 5

Hyperchylomicronemia Late Onset

Hyperlipemia Combined Fat And Carbohydrate-Induced

Hyperlipemia Mixed

Hyperlipidemia Type V

Mixed Hyperlipemia

Type V Hyperlipoproteinemia

Hyperlipoproteinemia 5

HLPP5

Hyperlipidemia, Familial Combined

Mixed Hyperlipidemia

Primary Biliary Cholangitis

Primary Biliary Cirrhosis

Biliary Liver Cirrhosis

Chronic Nonsuppurative Destructive Cholangitis

Familial Primary Biliary Cirrhosis

Pbc

Hanot Syndrome

Cholestatic Cirrhosis

Biliary Cirrhosis Primary

Liver Cirrhosis, Biliary

Hanot'S Cirrhosis

Biliary Cirrhosis

Pericholangiolic Biliary Cirrhosis

Tannhauser-Magendantz Syndrome

Hanot-Rossle Syndrome

Hypertrophic Cirrhosis

Todd Cirrhosis

Hanot Cirrhosis

Charcot Cirrhosis

Mahon-Tannhauser Syndrome

Toxic Cirrhosis

Hypertrophic Biliary Cirrhosis

Monolobular Cirrhosis

Unilobar Cirrhosis

Xanthomatous Biliary Cirrhosis

Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Myopathy

Muscular Diseases

Myopathies

Connective Tissue Disease

Connective Tissue Diseases

Connective Tissue Disorder

Abnormality Of Connective Tissue

Disorder Of Connective Tissue

Connective Tissue Disorders

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TRIM21 RGD RGD:1305795
Bos taurus TRIM21 VGNC VGNC:36319
Felis catus TRIM21 VGNC VGNC:66530
Mus musculus TRIM21 MGD MGI:106657
Macaca mulatta TRIM21 VGNC VGNC:78556
Canis familiaris TRIM21 VGNC VGNC:47808
Others TRIM21 NCBI