TSLP 蛋白, Cynomolgus (R127A, R130S, HEK293, His)

TSLP protein, as a cytokine, plays a key role in immune regulation. It induces monocytes to release T-cell attracting chemokines and significantly promotes the maturation of CD11c(+) dendritic cells. TSLP Protein, Cynomolgus (R127A, R130S, HEK293, His) is the recombinant cynomolgus-derived TSLP protein, expressed by HEK293 , with C-His labeled tag. The total length of TSLP Protein, Cynomolgus (R127A, R130S, HEK293, His) is 131 a.a., with molecular weight of 21-30 kDa.

TSLP（胸腺基质淋巴细胞生成素）蛋白是一种具有多种免疫调节功能的细胞因子。它诱导单核细胞释放吸引 T 细胞的趋化因子，并促进 CD11c(+) 树突状细胞的成熟，在免疫反应的调节中发挥着至关重要的作用。众所周知，TSLP 通过直接激活肥大细胞来影响过敏性炎症，从而促进复杂的过敏反应网络。TSLP通过与CRLF2和IL7R组成的受体复合物相互作用发挥作用，TSLP与CRLF2/TSLPR的结合是招募IL7R形成高亲和力三元复合物的机制先决条件。这些相互作用凸显了 TSLP 影响免疫细胞行为的复杂分子机制，强调了其在免疫系统调节和过敏反应中的作用。

Loaded Cynomolgus TSLP(R127A, R130S) on 96-Flat plate, can bind anti-TSLP antibody, with an affinity constant of 4.41 nM as determined in BLI assay (Gator Prime).

Cynomolgus

HEK293

C-His

A0A7N9CAT7 (Y29-Q159, R127A, R130S)

102119254  [NCBI]

21-30 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized a 0.22 μm filtered solution of PBS, 6% Trehalose, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.