TSLPR 蛋白, Cynomolgus (HEK293, His)

TSLPR protein is the receptor of TSLP and cooperates with IL7R to form a complex that activates STAT3 and STAT5 to stimulate cell proliferation. This receptor also activates JAK2, which is critical for the development of the hematopoietic system. TSLPR Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TSLPR protein, expressed by HEK293 , with C-His labeled tag. The total length of TSLPR Protein, Cynomolgus (HEK293, His) is 209 a.a., with molecular weight of 42-52 kDa.

TSLPR 蛋白作为胸腺基质淋巴细胞生成素 (TSLP) 的受体发挥作用，并与 IL7R 合作形成功能复合物，通过激活 STAT3 和 STAT5 刺激细胞增殖。此外，该受体激活 JAK2，在造血系统的发育中发挥着至关重要的作用。TSLPR 受体以 CRLF2 和 IL7R 的异二聚体形式存在，是高亲和力三元复合物的重要组成部分，其中 TSLP 与 CRLF2/TSLPR 的结合是招募 IL7R 的机制先决条件，突出了其在复杂的三元复合物中的关键作用。对细胞反应和造血发育至关重要的信号通路。

Immobilized Cynomolgus TSLPR, His Tag at 0.5 μg/mL (100 μl/well) on the plate. Dose response curve for Anti-TSLPR Antibody, hFc Tag with the EC₅₀ of <13.3 ng/mL determined by ELISA.

Cynomolgus

HEK293

C-His

XP_045239630.1 (Q23-K231)

123571109  [NCBI]

42-52 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.