TSPAN8 蛋白, Human (HEK293, His)

TSPAN8 is a cell surface glycoprotein that is complexed with integrins and belongs to the four-span protein family. It has four hydrophobic domains. TSPAN8 mediates extracellular signal transduction processes and regulates cell development, activation, growth, and movement. In addition, TSPAN8 is expressed in different cancers and has potential roles in cancer prognosis and targeted therapy. TSPAN8 Protein, Human (HEK293, His) is the recombinant human-derived TSPAN8 protein, expressed by HEK293 , with N-His, N-6*His labeled tag. The total length of TSPAN8 Protein, Human (HEK293, His) is 96 a.a., with molecular weight of ~17 & 13 kDa, respectively.

TSPAN8 通过激活 EGFR/AKT 通路，在促进肿瘤转移中发挥重要作用^[1]。
TSPAN8 通过靶向 mTORC2 来缓解高糖诱导的 HK-2 细胞自噬和凋亡 (apoptosis)^[2]。
TSPAN8 通过与自身和其他各种细胞信号分子相互作用形成TSPAN8 介导的蛋白复合物。这些蛋白质复合物有助于构建富含四跨膜蛋白的微区 (TEMs)，有效地介导细胞内信号转导。此外，TSPAN8 在调节白细胞迁移、血管生成和伤口修复等生物学功能中起着至关重要的作用^[3]。

Human

HEK293

N-His;N-6*His

P19075 (K110-N205)

7103  [NCBI]

KSKSDRIVNETLYENTKLLSATGESEKQFQEAIIVFQEEFKCCGLVNGAADWGNNFQHYPELCACLDKQRPCQSYNGKQVYKETCISFIKDFLAKN

Approximately 17&13 kDa

• 
  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in PBS, pH 7.4. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.