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  2. TSPAN8 - tetraspanin 8 Gene

TSPAN8 - tetraspanin 8 Gene

中文名称:四跨膜蛋白 8

种属: Homo sapiens

同用名: CO-029; TM4SF3

基因 ID: 7103 | 基因类型: protein coding

关于 TSPAN8

Cytogenetic location: 12q21.1 Genomic coordinates (GRCh38): 12:71,125,096-71,157,999 (from NCBI)

This gene has 7 transcripts (splice variants), 217 orthologues and 32 paralogues. Biased expression in colon (RPKM 463.8), duodenum (RPKM 388.7) and 5 other tissues.

功能概要

由该基因编码的蛋白质是跨膜 4 超家族的成员,也称为四跨膜蛋白家族。这些成员中的大多数是细胞表面蛋白,其特征在于存在四个疏水结构域。这些蛋白质介导在细胞发育、活化、生长和运动的调节中起作用的信号转导事件。这种编码的蛋白质是已知与整合素复合的细胞表面糖蛋白。该基因在不同的癌中表达。已发现该基因使用替代聚腺苷酸化位点。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

TSPAN8 基因产物(2)

mRNA Protein Name
NM_001369760.1 NP_001356689.1 tetraspanin-8
NM_004616.3 NP_004607.1 tetraspanin-8
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
27180358 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TSPAN8 蛋白结构

Tetraspannin

Tetraspannin: Tetraspanin family (7 - 234)

  • 0
  • 100
  • 200
  • 237 a.a.
蛋白主名 其他名称

tetraspanin-8

transmembrane 4 superfamily member 3

TSPAN8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TSPAN8 P19075 SLC38A7 Homo sapiens Q9NVC3 32296183
种属内
TSPAN8 P19075 STX2 Homo sapiens P32856-2 32296183
种属内
TSPAN8 P19075 PNLIPRP1 Homo sapiens P54315 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TSPAN8 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76117 TSPAN8 Protein, Human (HEK293, His) P19075 (K110-N205) ≥95%
HY-P76118 TSPAN8 Protein, Human (HEK293, Fc) P19075 (K110-N205) ≥95%

关联疾病

疾病名称 别名
Pancreas, Annular

Annular Pancreas

Pancreas Annulare

Congenital Annular Pancreas

Diabetes Mellitus

Diabetes

Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus TSPAN8 MGD MGI:2384918
Macaca mulatta TSPAN8 VGNC VGNC:78563
Canis familiaris TSPAN8 VGNC VGNC:47925
Bos taurus TSPAN8 VGNC VGNC:36442
Rattus norvegicus TSPAN8 RGD RGD:621783
Others TSPAN8 NCBI