TYRO3/DTK 蛋白, Human (388a.a, HEK293, His)

TYRO3/DTK protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as TULP1 or GAS6. TYRO3 is activated by ligand binding and regulates cell survival, migration, and differentiation, leading to dimerization and intracellular autophosphorylation to create docking sites for downstream signaling molecules. TYRO3/DTK Protein, Human (388a.a, HEK293, His) is the recombinant human-derived TYRO3/DTK protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TYRO3/DTK Protein, Human (388a.a, HEK293, His) is 388 a.a., with molecular weight of 55-70 kDa.

TYRO3/DTK 蛋白是一种受体酪氨酸激酶，通过与 TULP1 或 GAS6 等配体结合，将信号从细胞外基质传递到细胞质。它调节各种生理过程，包括细胞存活、迁移和分化。当配体与细胞表面的 TYRO3 结合时，会导致其胞内结构域二聚化和自磷酸化，为下游信号分子创建对接位点。这种激活还与 PIK3R1 相互作用，增强 PI3 激酶活性并激活 AKT 生存途径。该途径包括 NF-kappa-B 的核转位和 NF-kappa-B 调节基因的上调。TYRO3 信号传导参与保护神经元免受兴奋性毒性损伤、促进血小板聚集和重组细胞骨架。此外，TYRO3 在通过激活 STAT1 抑制 Toll 样受体 (TLR) 触发的先天免疫反应中发挥着至关重要的作用，STAT1 选择性诱导细胞因子信号转导 SOCS1 和 SOCS3 抑制剂的产生。还值得注意的是，TYRO3 可能通过 GAS6 与病毒体包膜表面的磷脂酰丝氨酸结合而发挥拉沙病毒和淋巴细胞性脉络丛脑膜炎病毒受体的作用。

Human

HEK293

C-6*His

Q06418 (A41-S428)

7301  [NCBI]

AGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTS

55-70 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.