2. Gene
  3. TYRO3 - TYRO3 protein tyrosine kinase Gene

TYRO3 - TYRO3 protein tyrosine kinase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TYRO3 蛋白酪氨酸激酶

种属: Homo sapiens

同用名: BYK; Dtk; RSE; Rek; Sky; Tif; Etk-2

基因 ID: 7301 | 基因类型: protein coding

关于 TYRO3

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,559,212-41,583,589 (from NCBI)

This gene has 9 transcripts (splice variants), 206 orthologues and 53 paralogues. Broad expression in ovary (RPKM 23.1), brain (RPKM 22.4) and 14 other tissues.

功能概要

该基因是 3 成员跨膜受体激酶受体家族的一部分，在 15 号染色体远端有一个经过加工的假基因。编码的蛋白质被生长停滞特异性基因 6 和蛋白 S 基因的产物激活，并参与控制细胞存活增殖、精子发生、免疫调节和吞噬作用。编码的蛋白质也被确定为埃博拉病毒和马尔堡病毒的细胞进入因子。[RefSeq 提供，2010 年 5 月]

The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]

TYRO3 基因产物(2)

mRNA Protein Name
NM_001330264.2 NP_001317193.1 tyrosine-protein kinase receptor TYRO3 isoform 2
NM_006293.4 NP_006284.2 tyrosine-protein kinase receptor TYRO3 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatidylinositol 3-kinase binding IPI
IPI: 通过物理相互作用推断
10627473 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
7634325 GOA
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
7537495 GOA
enables virus receptor activity IDA
IDA: 通过直接分析推断
22156524 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of viral life cycle IMP
IMP: 通过突变表型推断
22673088 GOA
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
7511603 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
7511603 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TYRO3 蛋白结构

I-set

I-set: Immunoglobulin I-set domain (48 - 124)

Ig_2

Ig_2: Immunoglobulin domain (141 - 220)

fn3

fn3: Fibronectin type III domain (227 - 307)

fn3

fn3: Fibronectin type III domain (324 - 406)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (519 - 785)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 890 a.a.
蛋白主名 其他名称

tyrosine-protein kinase receptor TYRO3

tyrosine-protein kinase DTK

TYRO3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TYRO3 Q06418 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
种属内
TYRO3 Q06418 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
种属内
TYRO3 Q06418 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
种属内
TYRO3 Q06418 KRTAP10-7 Homo sapiens P60409
Y2H Array
25416956
种属内
TYRO3 Q06418 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Prey Pooling
25416956
种属内
TYRO3 Q06418 KLK4 Homo sapiens Q9Y5K2
Y2H Prey Pooling
25416956
种属内
TYRO3 Q06418 KRTAP9-2 Homo sapiens Q9BYQ4
Validated Y2H
32296183
种属内
TYRO3 Q06418 HSP90AB1 Homo sapiens P08238
Lumier
22939624
种属内
TYRO3 Q06418 HSP90AB1 Homo sapiens P08238
Affinity Chrom
35384245
种属内
TYRO3 Q06418 KRTAP5-9 Homo sapiens P26371
Y2H
21516116
种属内
TYRO3 Q06418 KRTAP5-9 Homo sapiens P26371
Y2H Array
31515488
种属内
TYRO3 Q06418 GRB2 Homo sapiens P62993
Affinity Chrom
35384245
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TYRO3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70057 TYRO3/DTK Protein, Human (388a.a, HEK293, His) Q06418 (A41-S428) ≥95%
HY-P78657 TYRO3/DTK Protein, Human (Q261H, HEK293, Fc) Q06418/AAH51756.1 (A41-S428, Q261H) ≥95%

关联疾病

疾病名称 别名
Lymphocytic Choriomeningitis

Lcm

Lymphocytic Meningitis

Lymphocytic Choriomeningitis Virus Encephalomyelitis

Lymphocytic Meningoencephalitis

Non-Arthropod Borne Lymphocytic Choriomeningitis

Lcm - [Lymphocytic Choriomeningitis]

Benign Lymphocytic Meningitis

Meningitis Due To Lymphocytic Choriomeningitis Virus
Zika Fever

Zika Virus Infection

Zika Virus Disease

Zika Virus

Zika Virus Fever

Mosquito-Borne Viral Fever, Zika
La Crosse Encephalitis

California Encephalitis

California Virus Encephalitis

Neuroinvasive California Encephalitis Virus Infection

Californian Encephalitis

Encephalitis, California

California Meningoencephalitis

California Encephalitis Virus Infection

California Encephalitis Virus Infection Neuroinvasive Disease

California Meningoencephalitis Virus Disease

California Serogroup Virus Neuroinvasive Disease

California Viral Encephalitis

Ce - [California Encephalitis]

Lac - [La Crosse Encephalitis]
Retinal Degeneration

Degeneration Of Retina
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
Fundus Dystrophy

Retinal Dystrophy

Retinal Dystrophies

Dystrophy, Retinal
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-12076 BMS 777607 Inhibitor 99.33% Phase 2
HY-114358 Tamnorzatinib Inhibitor 98.07% Phase 2
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12494 LDC1267 Inhibitor 99.58% 否
HY-117596 UNC569 Inhibitor 99.87% 否
HY-132200 UNC5293 Inhibitor 98.78% 否
HY-117548 UNC1062 Inhibitor 99.48% 否
HY-124502 UNC4203 Inhibitor 99.80% 否
HY-162085 Axl-IN-17 Inhibitor / 否
HY-147218 PF-07265807 Inhibitor 97.13% 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TYRO3 RGD RGD:3923
Macaca mulatta TYRO3 VGNC VGNC:78683
Bos taurus TYRO3 VGNC VGNC:36551
Felis catus TYRO3 VGNC VGNC:66739
Mus musculus TYRO3 MGD MGI:104294
Canis familiaris TYRO3 VGNC VGNC:48027
Macaca fascicularis TYRO3 NCBI NCBI:102135978
Others TYRO3 NCBI
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