UBE2R2 蛋白, Human (His)

UBE2R2 Protein, a key element in the ubiquitin-proteasome system, operates as an E2 ubiquitin-conjugating enzyme. It accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to diverse protein substrates. In vitro, UBE2R2 displays versatile catalytic activity, facilitating both monoubiquitination and 'Lys-48'-linked polyubiquitination reactions. This implies its potential involvement in various cellular processes, including the targeted degradation of proteins, suggesting a role in the regulation of substrates like katenin. UBE2R2 Protein, Human (His) is the recombinant human-derived UBE2R2 protein, expressed by E. coli, with N-6*His labeled tag. The total length of UBE2R2 Protein, Human (His) is 238 a.a., with molecular weight of ~37.0 kDa.

UBE2R2 是泛素-蛋白酶体系统的一个组成部分，通过接受 E1 复合物中的泛素并催化其与不同蛋白质底物的共价附着，起到 E2 泛素结合酶的作用。在体外测定中，UBE2R2 表现出多种催化活性，促进单泛素化和“Lys-48”连接的多泛素化反应。这表明它可能参与各种细胞过程，包括蛋白质的靶向降解，这可能包括链蛋白或其他相关底物的调节。

Human

E. coli

N-6*His

Q712K3 (M1-S238)

54926  [NCBI]

MAQQQMTSSQKALMLELKSLQEEPVEGFRITLVDESDLYNWEVAIFGPPNTLYEGGYFKAHIKFPIDYPYSPPTFRFLTKMWHPNIYENGDVCISILHPPVDDPQSGELPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMFRKWRDSKGKDKEYAEIIRKQVSATKAEAEKDGVKVPTTLAEYCIKTKVPSNDNSSDLLYDDLYDDDIDDEDEEEEDADCYDDDDSGNEES

Approximately 37.0 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.