UBE2R2 - ubiquitin conjugating enzyme E2 R2 Gene

中文名称：泛素结合酶 E2 R2

种属: Homo sapiens

同用名: UBC3B; CDC34B; E2-CDC34B

关于 UBE2R2

功能概要

蛋白激酶 CK2 是一种普遍存在的多效性 Ser/Thr 蛋白激酶，参与细胞生长和转化。该基因编码一种类似于 E2 泛素结合酶 UBC3/CDC34 的蛋白质。研究表明，这种泛素结合酶的 CK2 依赖性磷酸化通过调节 β-TrCP 底物识别发挥作用，并诱导其与 β-TrCP 相互作用，从而增强 β-连环蛋白降解。[RefSeq 提供，2008 年 7 月]

Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating Enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating Enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]