1. 重组蛋白
  2. CD Antigens Receptor Proteins
  3. Endothelial cell CD Proteins
  4. U-PAR/CD87
  5. uPAR 蛋白, Cynomolgus (HEK293, His)

uPAR 蛋白, Cynomolgus (HEK293, His)

目录号: HY-P700897
产品使用指南

uPAR 蛋白是尿激酶纤溶酶原激活剂的受体,对纤溶酶的形成具有重要的定位和促进作用。它通过 U-PA 介导不依赖于蛋白水解的信号转导,并通过负反馈进行调节。uPAR 通常是单体,与 SRPX2、MRC2 相互作用,并在侵袭伪足处与 FAP 形成复合物,有助于蛋白水解和信号传导。它与 PLAU 和 SERPINE1 形成三元复合物,还与 SORL1 相互作用,突出了多方面的细胞功能。uPAR 蛋白, Cynomolgus (HEK293, His) 是重组的 uPAR 蛋白,由 HEK293 表达,带有 C-His 标签。uPAR 蛋白, Cynomolgus (HEK293, His) 全长 283 个氨基酸,分子量为 60-70 kDa。

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描述

uPAR Protein, a receptor for urokinase plasminogen activator, crucially localizes and facilitates plasmin formation. It mediates proteolysis-independent signal transduction by U-PA, regulated through negative feedback. uPAR, typically a monomer, interacts with SRPX2, MRC2, and forms a complex with FAP at invadopodia, contributing to proteolysis and signaling. It engages in a ternary complex with PLAU and SERPINE1, also interacting with SORL1, highlighting multifaceted cellular functions. uPAR Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived uPAR protein, expressed by HEK293, with C-His labeled tag. The total length of uPAR Protein, Cynomolgus (HEK293, His) is 283 a.a., with molecular weight of 60-70 kDa.

研究背景

uPAR 蛋白作为尿激酶纤溶酶原激活剂的受体,在定位和促进纤溶酶形成方面发挥着至关重要的作用。此外,它还介导 U-PA 的不依赖于蛋白水解的信号转导激活作用。受到 U-PA 的负反馈调节,uPAR 会裂解成非活性形式。它通常以单体形式存在,并与各种蛋白质相互作用,包括 SRPX2 和 MRC2。值得注意的是,它与侵袭伪足膜细胞表面的 FAP (seprase) 形成复合物,有助于参与蛋白水解和信号传导的细胞过程。此外,uPAR与PLAU(尿激酶型纤溶酶原激活剂)和SERPINE1形成三元复合物,并且该复合物还与SORL1相互作用,进一步凸显了其在细胞功能中的多方面相互作用。

种属

Cynomolgus

表达系统

HEK293

标签

C-His

蛋白编号

Q9GK78 (L23-G305)

基因 ID
蛋白结构
N-term
uPAR (L23-G305)
Accession # Q9GK78
His
C-term
同用名
U-PAR; uPAR; CD87; PLAUR; MO3; UPAR
分子量

60-70 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

uPAR Protein, Cynomolgus (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
uPAR Protein, Cynomolgus (HEK293, His)
目录号:
HY-P700897
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