uPAR 蛋白, Mouse (HEK293, His)

The uPAR protein acts as a receptor for urokinase plasminogen activator, facilitating plasmin formation and signal transduction activation.It interacts with SRPX2 and forms a monomer.uPAR also interacts with MRC2 and SORL1, reducing PLAUR internalization.Additionally, the PLAUR-PLAU-SERPINE1 complex interacts with SORL1.uPAR Protein, Mouse (HEK293, His) is the recombinant mouse-derived uPAR protein, expressed by HEK293 , with C-His labeled tag.

uPAR 蛋白作为尿激酶纤溶酶原激活剂的受体发挥作用，在纤溶酶的定位和促进形成中起着至关重要的作用。此外，它介导 U-PA 的信号转导激活作用，与蛋白水解无关。它主要作为单体存在，并通过其 UPAR/Ly6 结构域与 SRPX2 相互作用。uPAR 还与 MRC2 和 SORL1 相互作用，后者相互作用减少 PLAUR 内化。此外，由PLAUR-PLAU-SERPINE1组成的三元复合物也与SORL1相互作用。

Measured by its ability to bind with uPA-His in a functional ELISA.

Mouse

HEK293

C-His

P35456 (M1-T297)

18793  [NCBI]

50-60 kDa

Greater than 95% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.