USAG-1 蛋白, Human (HEK293, Fc)

USAG-1 protein is involved in initiating endometrial receptivity, contributing to implantation preparation and decidual cell response sensitization. It regulates signaling pathways by enhancing Wnt signaling while inhibiting TGF-β signaling. USAG-1 Protein, Human (HEK293, Fc) is the recombinant human-derived USAG-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of USAG-1 Protein, Human (HEK293, Fc) is 183 a.a., with molecular weight of 55-70 kDa.

USAG-1 蛋白似乎与子宫内膜容受性的启动有关，可能有助于植入的准备和蜕膜细胞反应的致敏。此外，它还通过增强 Wnt 信号传导并同时抑制 TGF-β 信号传导来调节信号传导途径。值得注意的是，USAG-1 以剂量依赖性方式作为 BMP2、BMP4、BMP6 和 BMP7 的直接拮抗剂，表明在 BMP 信号通路中具有调节功能。它与 BMP2、BMP4、BMP6 和 BMP7 具有高亲和力相互作用，表明直接参与这些信号分子的调节。

Measured by its binding ability in a functional ELISA. When Recombinant Human USAG1 is coated at 2 μg/mL (100 μL/well), the concentration of rhLRP-6 that produces 50% of the optimal binding response is found to be approximately 0.0323 μg/mL.

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  Measured by its binding ability in a functional ELISA. When Recombinant Human USAG1 is coated at 2 μg/mL (100 μL/well), the concentration of rhLRP-6 that produces 50% of the optimal binding response is found to be approximately 0.0323 μg/mL.

Human

HEK293

C-hFc

Q6X4U4-1 (F24-S206)

/

FKNDATEILYSHVVKPVPAHPSSNSTLNQARNGGRHFSNTGLDRNTRVQVGCRELRSTKYISDGQCTSISPLKELVCAGECLPLPVLPNWIGGGYGTKYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKCKRYTRQHNESSHNFESMSPAKPVQHHRERKRASKSSKHSMS

Approximately 55-70 kDa due to the glycosylation.

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.