2. 重组蛋白
  3. Cytokines and Growth Factors CAR-T related Proteins Receptor Proteins Enzymes & Regulators
  4. VEGF & VEGFR Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. VEGFR
  6. FLK-1/VEGFR-2 FLK-1/VEGFR-2
  7. VEGFR-2 蛋白, Rat (HEK293, Fc)

VEGFR-2 蛋白, Rat (HEK293, Fc)

目录号: HY-P73481
产品使用指南

VEGFR-2 Protein一种 III 型受体酪氨酸激酶, 也称为血管内皮生长因子的受体 2。VEGFR-2 蛋白 介导血管内皮生长因子 (VEGF) 诱导的内皮增殖、存活、迁移、管状形态发生和发芽，在血管发生和血管生成中起着关键作用。VEGFR-2 蛋白, Rat (HEK293, Fc) 是重组的 VEGFR-2 蛋白，由 HEK293 表达，带有 C-hFc 标签。

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100 μg   询价  

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描述

VEGFR-2 Protein is a type III receptor tyrosine kinase, also known as the receptor for vascular endothelial growth factor 2.VEGFR-2 Protein mediates vascular endothelial growth factor (VEGF)-induced endothelial proliferation, survival, migration, tubular morphogenesis, and sprouting, and plays a key role in angiogenesis and vasculogenesis.VEGFR-2 Protein, Rat (HEK293, Fc) is the recombinant rat-derived VEGFR-2 protein, expressed by HEK293 , with C-hFc labeled tag.
研究背景

VEGFR-2 Protein 介导血管内皮生长因子 (VEGF) 诱导的内皮增殖、存活、迁移、管状形态发生和发芽, 在血管发生和血管生成中起着关键作用[1][3]。
VEGFR-2 Protein 的信号在海马神经元中是一种促进生存的机制，可以防止线粒体功能障碍和氧化应激[2]。
VEGFR-2 Protein 在糖尿病微血管中的表达较高，可以作为早期糖尿病视网膜病变 (DR) 诊断的生物标志物[4]。
VEGFR-2 Protein 介导硫化氢 (H2S) 诱导的大鼠脑基底动脉扩张[5]。
种属

Rat
表达系统

HEK293
标签

C-hFc
蛋白编号

AAH87029.1 (M1-E760)
基因 ID
蛋白结构
N-term
VEGFR-2 (M1-E760)
Accession # AAH87029.1
hFc
C-term
同用名
Vascular endothelial growth factor receptor 2; KDR; VEGFR-2; FLK-1; CD309
分子量

Approximately 110 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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