Kdr - kinase insert domain receptor Gene

中文名称：激酶插入域受体

种属: Rattus norvegicus

同用名: Vegfr-2

关于 Kdr

功能概要

该基因编码的蛋白可启动生长因子结合活性和血管内皮生长因子激活受体活性。涉及多个过程，包括神经元的生成；内皮细胞增殖的正向调节；和细胞内信号转导的正调控。位于多个细胞成分中，包括神经元投射；神经细胞体；和质膜。用于研究子宫粘连；脑缺血;膀胱炎;和心肌梗塞。多种疾病的生物标志物，包括动脉疾病（多种）；阳痿;卵巢过度刺激综合征；前列腺疾病（多种）；和早产儿视网膜病变。该基因的人类直系同源物与多种疾病有关，包括动脉疾病（多种）；胃肠系统癌症（多发性）；胶质母细胞瘤;黄斑变性（多发性）；和胰腺癌（多发）。与人类 KDR（激酶插入域受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables growth factor binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including generation of neurons; positive regulation of endothelial cell proliferation; and positive regulation of intracellular signal transduction. Located in several cellular components, including neuron projection; neuronal cell body; and plasma membrane. Used to study adhesions of uterus; brain ischemia; cystitis; and myocardial infarction. Biomarker of several diseases, including artery disease (multiple); impotence; ovarian hyperstimulation syndrome; prostate disease (multiple); and retinopathy of prematurity. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); gastrointestinal system Cancer (multiple); glioblastoma; macular degeneration (multiple); and pancreatic Cancer (multiple). Orthologous to human VEGFR2/KDR/Flk-1 (kinase insert domain receptor). [provided by Alliance of Genome Resources, Apr 2022]