1. Protein Tyrosine Kinase/RTK Autophagy Apoptosis
  2. VEGFR Autophagy Apoptosis
  3. Vandetanib-d6

Vandetanib-d6  (Synonyms: ZD6474-d6)

目录号: HY-10260S
产品使用指南

Vandetanib-d6 是 Vandetanib 的氘代物。Vandetanib (D6474) 是一种有效的,具有口服活性的 VEGFR2/KDR 酪氨酸激酶抑制剂 (IC50=40 nM)。Vandetanib 也抑制 VEGFR3/FLT4 (IC50=110 nM) 和 EGFR/HER1 (IC50=500 nM)

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Vandetanib-d<sub>6</sub> Chemical Structure

Vandetanib-d6 Chemical Structure

CAS No. : 1174683-49-8

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规格 价格 是否有货
500 μg ¥5000
询问价格 & 货期

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Customer Review

Other Forms of Vandetanib-d6:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vandetanib-d6 is the deuterium labeled Vandetanib. Vandetanib (D6474) is a potent, orally active inhibitor of VEGFR2/KDR tyrosine kinase activity (IC50=40 nM). Vandetanib also has activity versus the tyrosine kinase activity of VEGFR3/FLT4 (IC50=110 nM) and EGFR/HER1 (IC50=500 nM)[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

481.39

Formula

C22H18D6BrFN4O2

CAS 号
非标记 CAS

443913-73-3

中文名称

凡德他尼 d6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Vandetanib-d6
目录号:
HY-10260S
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