2. Protein Tyrosine Kinase/RTK
  3. FLT3 PDGFR VEGFR
  4. Multi-kinase inhibitor 3

Multi-kinase inhibitor 3 (compound 12) 是一种有效的和具有口服活性的多激酶 (multikinase) 抑制剂，对 FLT1/VEGFR1、KDR/VEGFR2、FLT4/VEGFR3、FLT3、PDGFRα、PDGFRβ 的 IC50 值分别为 1.59、1.23、1.19、0.59、0.22、1.15 nM。Multi-kinase inhibitor 3 具有抗增殖活性。Multi-kinase inhibitor 3 具有抗癌活性。

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Multi-kinase inhibitor 3 Chemical Structure

Multi-kinase inhibitor 3 Chemical Structure

CAS No. : 2648279-76-7

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Multi-kinase inhibitor 3 相关抗体

Top Publications Citing Use of Products

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PDGFR PDGFRβ PDGFRα

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Multi-kinase inhibitor 3 (compound 12) is a potent and orally active multikinase inhibitor with IC50 values of 1.59, 1.23, 1.19, 0.59, 0.22, 1.15 nM for FLT1/VEGFR1, KDR/VEGFR2, FLT4/VEGFR3, FLT3, PDGFRα, PDGFRβ, respectively. Multi-kinase inhibitor 3 shows antiproliferative activity. Multi-kinase inhibitor 3 shows anticancer activity[1].

IC50 & Target[1]

VEGFR1

1.59 nM (IC50)

VEGFR2

1.23 nM (IC50)

VEGFR3

1.19 nM (IC50)

PDGFRα

0.22 nM (IC50)

PDGFR-β

1.15 nM (IC50)

分子量

454.52

Formula

C26H26N6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Multi-kinase inhibitor 3 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multi-kinase inhibitor 32648279-76-7FLT3PDGFRVEGFRCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Platelet-derived growth factor receptorVascular endothelial growth factor receptorHuh-7HepG2Hep3B cellsantiproliferativeanticancerorally activeInhibitorinhibitorinhibit

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