VSIG2 蛋白, Human (HEK293, His)

VSIG2 is also known as CTXL (cortical thymocyte like-protein). VSIG2 promotes malignant progression of pancreatic ductal adenocarcinoma through LAMtor2-mediated mTOR activation. VSIG2 can be used as a potential biomarker or therapeutic target for tumors. VSIG2 Protein, Human (HEK293, His) is the recombinant human-derived VSIG2 protein, expressed by HEK293 , with C-6*His labeled tag.

V-set and immunoglobulin domain-containing protein 2 也称为皮质胸腺细胞样蛋白、CT 样蛋白和VSIG2，是一种单代 I 型膜蛋白。VSIG2 在胃和结肠中高表达，在膀胱和肺中表达较弱。VSIG2 与结肠癌 (COAD) 的免疫侵袭和抗原呈递相关，它可以作为 COAD 的潜在生物标志物或治疗靶点。VSIG2 通过 LAMTOR2 介导的 mTOR 激活促进胰腺导管腺癌的恶性进展。VISG2 与多种疾病相关，在Fuchs 内皮性角膜营养不良 (FECD) 患者的角膜样本中，在肠易激综合征 (IBS-D) 患者的肠道活检中，在急性小管损伤和间质纤维化/小管萎缩患者的血浆中，以及在突发心力衰竭患者的血浆中，VSIG2 被发现显著上调。

Human

HEK293

C-6*His

Q96IQ7-1 (V24-A243)

23584  [NCBI]

VEVKVPTEPLSTPLGKTAELTCTYSTSVGDSFALEWSFVQPGKPISESHPILYFTNGHLYPTGSKSKRVSLLQNPPTVGVATLKLTDVHPSDTGTYLCQVNNPPDFYTNGLGLINLTVLVPPSNPLCSQSGQTSVGGSTALRCSSSEGAPKPVYNWVRLGTFPTPSPGSMVQDEVSGQLILTNLSLTSSGTYRCVATNQMGSASCELTLSVTEPSQGRVA

29-35 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.